UWORLD random 3/21a

Question 1

Cl shift

Answer 1

RBCs

carbonic anhydrase

CO2 –> HCO3 –> HCO3 + H+

bicarb diffuses out of RBC and Cl- takes its place to maintain electrical neutrality

high RBC chloride in venous blood

Question 2

sarcoidosis (mediated by, labs, imaging)

Answer 2

CD4+

noncaseating granulomas

+ ACE
hypercalcemia

bilateral hilar adenopathy

Question 3

IFN-y released by…

Answer 3

activated T lymphocytes

Question 4

postprandial epigastric pain
food + aversion/weight loss
in setting of general atherosclerosis

Answer 4

chronic mesenteric ischemia

similar to stable angina

Question 5

HIV viral genes

Answer 5

Tat = replication

Nef = decrease MHC I

Question 6

rifampin MoA

Answer 6

inhibit bacterial DNA dependent RNA pol

Question 7

marfan syndrome defect

Answer 7

fibrillin-1

microfibrils

Question 8

fulminant hep in pregnant women

Answer 8

HEP E

unenveloped

vowels hit your bowels

Question 9

VHL

Answer 9

chr 3

renal cell carcinoma

Question 10

c MYC

Answer 10

chr 8

burkitt
diffuse large B cell lymphoma

Question 11

NF-1

Answer 11

chr 17

NF type 1

Question 12

RB

Answer 12

chr 13

retinoblastoma
osteosarcoma

Question 13

WT-1

Answer 13

chr 11

wilms tumor

Question 14

antioxidant enzymes

Answer 14

superoxide dismutase
glutathione peroxidase
catalase

Question 15

scopolamine indication

Answer 15

motion sickness

Question 16

spleen embryo origin

Answer 16

mesoderm