hyperlipidemia drugs Flashcards
statins MoA
inhibit HMG-CoA reductase
statins effects
- LDL
- TGs
statins ADR
hepatotoxicity
muscle toxicity
ezetimibe MoA
lower intestinal cholesterol absorption
ezetimibe effects
- LDL
ezetimibe ADR
hepatotoxicity if given with statins
bile acid sequestrants
cholestyramine
bile acid sequestrants MoA
prevent reabsorption of bile acids in the intestine
bile acid sequestrants effects
- LDL
bile acid sequestrants ADR
nausea, bloating, cramping
impaired absorption of drug & fat-soluble vitamins
niacin MoA
- FA release
- VLDL synthesis
- HDL clearance
niacin effects
- LDL
++ HDL
niacin ADR
flushing, pruritis
hepatotoxicity
hyperuricemia/gout
fibrates
gemfibrozil
fenofibrate
fibrates MoA
activate PPAR-a –> upregulate LPL
- VLDL synthesis
fibrates effects
– TGs
+ HDL
fibrates ADR
muscle toxicity
gallstones
fish oil MoA
- VLDL synthesis
- ApoB synthesis
fish oil effects
- TGs
+ HDL