hyperlipidemia drugs Flashcards
1
Q
statins MoA
A
inhibit HMG-CoA reductase
2
Q
statins effects
A
- LDL
- TGs
3
Q
statins ADR
A
hepatotoxicity
muscle toxicity
4
Q
ezetimibe MoA
A
lower intestinal cholesterol absorption
5
Q
ezetimibe effects
A
- LDL
6
Q
ezetimibe ADR
A
hepatotoxicity if given with statins
7
Q
bile acid sequestrants
A
cholestyramine
8
Q
bile acid sequestrants MoA
A
prevent reabsorption of bile acids in the intestine
9
Q
bile acid sequestrants effects
A
- LDL
10
Q
bile acid sequestrants ADR
A
nausea, bloating, cramping
impaired absorption of drug & fat-soluble vitamins
11
Q
niacin MoA
A
- FA release
- VLDL synthesis
- HDL clearance
12
Q
niacin effects
A
- LDL
++ HDL
13
Q
niacin ADR
A
flushing, pruritis
hepatotoxicity
hyperuricemia/gout
14
Q
fibrates
A
gemfibrozil
fenofibrate
15
Q
fibrates MoA
A
activate PPAR-a –> upregulate LPL
- VLDL synthesis
