UWORLD Cardio Pharm 3/14a Flashcards
1
Q
Dobutamine receptor effect
A
- B1 agonist
- weak B2, a1 agonist
2
Q
Dobutamine MoA
A
- Gs –> activate adenylyl cyclase –> + cAMP
- increase Na & Ca channel activation in nodes
3
Q
Dobutamine effects
A
- increase contractility
- increase HR
- increase CO
- B2 > a1 = mild vasodilation –> decrease SVR
4
Q
Dobutamine indications
A
- LV systolic dysfunction
- cardiogenic shock
5
Q
Digoxin MoA
A
- inhibit Na/K ATPase
- decrease Na efflux
- decrease activity of Na/Ca exchanger
- decrease Ca efflux
- increased intracellular Ca
- activate vagus nerve
- increase parasympa tone
6
Q
Digoxin effects
A
- positive inotropy
- slow conduction thru AV node
7
Q
Digoxin toxicity
A
- nonspecific = nausea, ab pain, fatigue, dizziness, confusion, blurred vision, abnormal color perception
- cardiac arrhythmias = bradycardia, junctional escape beats (AV node block)
- hyperkalemia
8
Q
chlorthalidone?
A
thiazide
9
Q
thiazide MoA
A
- inhibit Na/Cl cotransporters in distal convoluted tubule
- decrease reabsorption of Na & Cl
10
Q
Thiazide effects
A
- decrease intravascular volume
- reduce CO
- lower SVR
- lower BP
11
Q
thiazides - raise? lower?
A
raise
- calcium
- uric acid
- glucose
- LDL
- TGs
lower
- sodium
- potassium
- magnesium
12
Q
arteriolar vasodilators
A
hydralazine
minoxidil
13
Q
arteriolar vasodilator effects
A
- reduce SVR
- lower BP
14
Q
arteriolar vasodilator ADR
A
- stimulate baroreceptors = reflex sympa tone
- increased HR, contractility, CO
- stimulate RAAS = Na/fluid retention & peripheral edema
15
Q
arteriolar vasodilator indications
A
- acute severely elevated BP
- combo with sympatholytics & diuretics for resistant HTN
