UWORLD random 3/20b

Question 1

actin & myosin bound to structural proteins where?

Answer 1

actin = z-line

myosin = M line

Question 2

pancreas embryology

dorsal vs ventral buds

Answer 2

dorsal = tail, body, most of head, small accessory duct

ventral = uncinate process, portion of head, prox portion of main duct

fuse in 8th week

Question 3

immune response to TB mediated by…

Answer 3

CD4+ T cells

macrophages –> langhans giant cells

Question 4

thrombus in a fib formed where?

Answer 4

left atrial appendage

Question 5

efficacy

Answer 5

intrinsic ability of drug to elicit effect

max ceiling of activity irrespective to dose

Question 6

potency

Answer 6

dose of drug required to produce given effect

limited by affinity – higher affinity = higher potency

Question 7

parasites that cause disease in RBCs

Answer 7

plasmodium

babesiosis

Question 8

babesiosis sx

Answer 8

flu
myalgias
headache
fever
fatigue

anemia
thrombocytopenia
+ LFTs

splenomegaly

NE USA

Question 9

dx mucormycosis

Answer 9

histology of affected tissue

broad nonseptate hyphae with right angle branching

Question 10

time period for dx major depressive disorder

Answer 10

> 2 weeks

Question 11

dermatomyositis

Answer 11

autoimmune
inflammatory myopathy

pottron papules = joints, bony prominences
heliotrop rash = eyelids
myopathy = prox muscle weakness

anti-jo-1
ANA

Question 12

intraabdominal infxn most common pathogen

Answer 12

b fragilis

e coli

Question 13

short - intermed term benzos

Answer 13

tria
oxa
mida

alpra
lora
tema

Question 14

long acting benzos

Answer 14

dia
chlordia
flura

Question 15

CF mutation

Answer 15

impaired post translational processing of CFTR

delete Phe at 508

Question 16

neurophysin

Answer 16

carrier proteins for oxytocin and vasopressin to release from post pit

mut = AD hereditary hypothalamic diabetes insipidus

Question 17

anthracyclines ADR

Answer 17

-rubicin

free radicals –>
severe cardiotoxicity = dilated cardiomyopathy

Question 18

monitor hydatidiform moles via

Answer 18

b-hCG

Question 19

shoulder trauma nerve injury

Answer 19

axillary nerve

sensory loss over lateral shoulder and weakness on shoulder abduction

Question 20

Kawasaki disease complication

Answer 20

coronary artery disease

Question 21

Kawasaki disease sx

Answer 21

fever >5 days
bilateral non-exudative conjunctival injection
cervical lymphadenopathy
mucositosis
extremity changes
rash

asians

Question 22

foscarnet

Answer 22

pyrophosphate analog that does not require intracellular activation

directly inhibits DNA pol and reverse transcriptase

Question 23

intranuclear and intracytoplasmic inclusions

Answer 23

CMV

Question 24

inhaled anesthetic hepatotoxicity

Answer 24

halothane

fulminant hepatitis
shrunken liver

fever, anorexia, nausea, myalgias, arthralgias, rash
jaundice
\+ ALT,AST
\+ PTT
leukocytosis, eosinophilia

Question 25

methemoglobinemia - normal arterial blood values?

Answer 25

partial pressure of oxygen in blood methemoglobin cannot bind oxygen

Question 26

menorrhagia and epistaxis as a kid

Answer 26

vWF deficiency

Question 27

vWF binds...

Answer 27

glycoproteins and collagen carries factor VIII

Question 28

latanoprost

Answer 28

topical PG treats open angle glaucoma increase outflow of aqueous humor

Question 29

NF-kB

Answer 29

proinflam transcription factor increase cytokine production inhibited in Crohns with NOD2 mutations

Question 30

mitral valve stenosis murmur

Answer 30

opening snap diastolic rumbling apex

Question 31

osmotic laxative mimics...

Answer 31

lactase deficiency polyethylene glycol magnesium hydroxide

Question 32

benzos DDI

Answer 32

first gen H1 antagonists diphenhydramine chlorpheniramine

Question 33

"water under the bridge"

Answer 33

uterine artery grosses over anterior surface of ureter

Question 34

complications of varicose veins

Answer 34

``` painful thromboses stasis dermatitis skin ulcerations poor wound healing superficial infections ```

Question 35

Neimman Pick

Answer 35

AR sphingomyelinase deficiency hepatosplenomegaly CNS sx cherry red macular spot Ashkenazi Jews

Question 36

a/p stenosis murmur

Answer 36

crescendo decrescendo systolic murmuer

Question 37

bladder cancer prognosis markers

Answer 37

** degree of invasion

Question 38

motor innervation of tongue

Answer 38

hypoglossal nerve palatoglossus = vagus

Question 39

general sensory innervation of tongue

Answer 39

ant 2/3 = CNV3 post 1/3 = glossopharyngeal post tongue root = vagus

Question 40

taste innervation of tongue

Answer 40

ant 2/3 = chorda tympani of facial post 1/3 = glossopharyngeal post tongue root/larynx/upper esophagus = vagus

Question 41

plasma cell neoplasm

Answer 41

multiple myeloma = RBC rouleaux, Bence-Jones proteins in urine anemia, lytic bone lesions, renal insufficiency