UWORLD random 3/20b Flashcards
actin & myosin bound to structural proteins where?
actin = z-line
myosin = M line
pancreas embryology
dorsal vs ventral buds
dorsal = tail, body, most of head, small accessory duct
ventral = uncinate process, portion of head, prox portion of main duct
fuse in 8th week
immune response to TB mediated by…
CD4+ T cells
macrophages –> langhans giant cells
thrombus in a fib formed where?
left atrial appendage
efficacy
intrinsic ability of drug to elicit effect
max ceiling of activity irrespective to dose
potency
dose of drug required to produce given effect
limited by affinity – higher affinity = higher potency
parasites that cause disease in RBCs
plasmodium
babesiosis
babesiosis sx
flu myalgias headache fever fatigue
anemia
thrombocytopenia
+ LFTs
splenomegaly
NE USA
dx mucormycosis
histology of affected tissue
broad nonseptate hyphae with right angle branching
time period for dx major depressive disorder
> 2 weeks
dermatomyositis
autoimmune
inflammatory myopathy
pottron papules = joints, bony prominences
heliotrop rash = eyelids
myopathy = prox muscle weakness
anti-jo-1
ANA
intraabdominal infxn most common pathogen
b fragilis
e coli
short - intermed term benzos
tria
oxa
mida
alpra
lora
tema
long acting benzos
dia
chlordia
flura
CF mutation
impaired post translational processing of CFTR
delete Phe at 508
neurophysin
carrier proteins for oxytocin and vasopressin to release from post pit
mut = AD hereditary hypothalamic diabetes insipidus
anthracyclines ADR
-rubicin
free radicals –>
severe cardiotoxicity = dilated cardiomyopathy
monitor hydatidiform moles via
b-hCG
shoulder trauma nerve injury
axillary nerve
sensory loss over lateral shoulder and weakness on shoulder abduction
Kawasaki disease complication
coronary artery disease
Kawasaki disease sx
fever >5 days bilateral non-exudative conjunctival injection cervical lymphadenopathy mucositosis extremity changes rash
asians
foscarnet
pyrophosphate analog that does not require intracellular activation
directly inhibits DNA pol and reverse transcriptase
intranuclear and intracytoplasmic inclusions
CMV
inhaled anesthetic hepatotoxicity
halothane
fulminant hepatitis
shrunken liver
fever, anorexia, nausea, myalgias, arthralgias, rash jaundice \+ ALT,AST \+ PTT leukocytosis, eosinophilia
methemoglobinemia - normal arterial blood values?
partial pressure of oxygen in blood
methemoglobin cannot bind oxygen
menorrhagia and epistaxis as a kid
vWF deficiency
vWF binds…
glycoproteins and collagen
carries factor VIII
latanoprost
topical PG treats open angle glaucoma
increase outflow of aqueous humor
NF-kB
proinflam transcription factor
increase cytokine production
inhibited in Crohns with NOD2 mutations
mitral valve stenosis murmur
opening snap
diastolic rumbling
apex
osmotic laxative mimics…
lactase deficiency
polyethylene glycol
magnesium hydroxide
benzos DDI
first gen H1 antagonists
diphenhydramine
chlorpheniramine
“water under the bridge”
uterine artery grosses over anterior surface of ureter
complications of varicose veins
painful thromboses stasis dermatitis skin ulcerations poor wound healing superficial infections
Neimman Pick
AR
sphingomyelinase deficiency
hepatosplenomegaly
CNS sx
cherry red macular spot
Ashkenazi Jews
a/p stenosis murmur
crescendo decrescendo systolic murmuer
bladder cancer prognosis markers
** degree of invasion
motor innervation of tongue
hypoglossal nerve
palatoglossus = vagus
general sensory innervation of tongue
ant 2/3 = CNV3
post 1/3 = glossopharyngeal
post tongue root = vagus
taste innervation of tongue
ant 2/3 = chorda tympani of facial
post 1/3 = glossopharyngeal
post tongue root/larynx/upper esophagus = vagus
plasma cell neoplasm
multiple myeloma = RBC rouleaux, Bence-Jones proteins in urine
anemia, lytic bone lesions, renal insufficiency
