UWORLD Cardio Pharm 3/14b Flashcards
niacin ADR = flushing mediated by
tx?
prostaglandins
PGD2, PGE2
tx with aspirin
nitroglycerin MoA & fxn
venodilator –> decrease preload –> decrease cardiac workload
large veins
ARBs target
ATII receptors
ARBs RAAS effect
+ ATII
+ ATI
+ Renin
- Aldosterone
low dose aspirin MoA and fxn
inhibit COX-1
inhibit synthesis of TXA2
impair platelet aggregation
reduce vasoconstriction
aspirin ADR
GI bleeding
transient ischemic attack sx
hx hypertension, hypercholesterolemia
sx sudden onset neuro deficits = limb weakness, difficulty speaking
CYP450 inducers
carbamazepine phenobarbital phenytoin rifampin griseofulvin
CYP450 inhibitors
cimetidine ciprofloxacin erythromycin azoles grapefruit juice isoniazid ritonavir
Statin metabolism
CYP450 3A4
except pravastatin
statin + CYP450 inhibitor
myopathy
rhabdomyolysis –> acute renal failure
class I antiarrhythmics Na+ channel binding strength (most –> least)
1C > 1A > 1B
alteplase MoA
thrombolytic
bind fibrin & convert plasminogen –> plasmin
plasmin hydrolyzes bonds in fibrin –> clot lysis
alteplase ADR
hemorrhage
dihydropyridine ADR
peripheral edema
headache, flushing, dizziness
preferential dilation of precapillary vessels (arteriolar dilation) –> + hydrostatic pressure & fluid accumulation in interstitium