UWORLD Cardio Pharm 3/14b Flashcards

1
Q

niacin ADR = flushing mediated by

tx?

A

prostaglandins
PGD2, PGE2

tx with aspirin

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2
Q

nitroglycerin MoA & fxn

A

venodilator –> decrease preload –> decrease cardiac workload

large veins

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3
Q

ARBs target

A

ATII receptors

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4
Q

ARBs RAAS effect

A

+ ATII
+ ATI
+ Renin
- Aldosterone

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5
Q

low dose aspirin MoA and fxn

A

inhibit COX-1
inhibit synthesis of TXA2

impair platelet aggregation
reduce vasoconstriction

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6
Q

aspirin ADR

A

GI bleeding

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7
Q

transient ischemic attack sx

A

hx hypertension, hypercholesterolemia

sx sudden onset neuro deficits = limb weakness, difficulty speaking

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8
Q

CYP450 inducers

A
carbamazepine
phenobarbital
phenytoin
rifampin
griseofulvin
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9
Q

CYP450 inhibitors

A
cimetidine
ciprofloxacin
erythromycin
azoles
grapefruit juice
isoniazid
ritonavir
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10
Q

Statin metabolism

A

CYP450 3A4

except pravastatin

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11
Q

statin + CYP450 inhibitor

A

myopathy

rhabdomyolysis –> acute renal failure

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12
Q

class I antiarrhythmics Na+ channel binding strength (most –> least)

A

1C > 1A > 1B

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13
Q

alteplase MoA

A

thrombolytic

bind fibrin & convert plasminogen –> plasmin
plasmin hydrolyzes bonds in fibrin –> clot lysis

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14
Q

alteplase ADR

A

hemorrhage

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15
Q

dihydropyridine ADR

A

peripheral edema
headache, flushing, dizziness

preferential dilation of precapillary vessels (arteriolar dilation) –> + hydrostatic pressure & fluid accumulation in interstitium

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