UWORLD random 3/18 Flashcards by Mai Nguyen

location of rRNA transcription

nucleolus

How well did you know this?

Not at all

Perfectly

% values that lie within 1 standard deviation…

within 2?

within 3?

68%

95%

99.7%

How well did you know this?

Not at all

Perfectly

___ composes most of the right side of cardiac silhouette

right atrium

How well did you know this?

Not at all

Perfectly

consolidation in RML can obscure x-ray silhouette of…

right heart border

mostly right atrium

How well did you know this?

Not at all

Perfectly

sydenham chorea

acute rheumatic fever

non-rhythmic movements of hands, feet, face

sudden changes in voice pitch and volume

How well did you know this?

Not at all

Perfectly

erythema marginatum

erythematous, circular lesions with central clearing on trunk and extremities

How well did you know this?

Not at all

Perfectly

acute rheumatic fever

immune-mediated disease following untreated Group A strep

molecular mimcry against M protein & N-acetyl-beta-D-glucosamine –> myosin, lysoganglioside

How well did you know this?

Not at all

Perfectly

length constant

measure of how far along an axon an electrical impulse can propagate

myelination = ++

How well did you know this?

Not at all

Perfectly

langerhans cells

dendritic cell in skin and mucous membranes

APCs

myeloid cell line

Birbeck granules

How well did you know this?

Not at all

Perfectly

Birbeck granules

characteristic racquet-shaped intracytoplasmic granules

How well did you know this?

Not at all

Perfectly

desmopression tx in bleeding

mild hemophilia & type 1 vWF disease

increase circulating FVIII & endothelial secretion of vWF to stop bleeding

How well did you know this?

Not at all

Perfectly

GDP –> GTP in TCA cycle

succinyl-CoA –> succinate

How well did you know this?

Not at all

Perfectly

oxaloacetate –> PEP

requires GTP

PEP carboxykinase

How well did you know this?

Not at all

Perfectly

blunt aortic injury

MV accidents

injury at aortic isthmus which is immobile compared to adjacent decending aorta

How well did you know this?

Not at all

Perfectly

porphyria cutanea tarda (PCT)

most common disorder of heme synthesis

uroporphyrinogen decarboxylase deficiency
(late step)

photosensitivity, blisters, edema, pruritis, pain, erythema

How well did you know this?

Not at all

Perfectly

cardiac tamponade sx

hypotension
tachycardia
JVD with clear lungs
pulsus paradoxus

How well did you know this?

Not at all

Perfectly

postpartum depression timeline

5-10 days after delivery = postpartum blues

2-4 weeks = postpartum depression

How well did you know this?

Not at all

Perfectly

absence of CD18 antigens

leukocyte adhesion deficiency

How well did you know this?

Not at all

Perfectly

LAD

recurrent skin, mucosal infections
periodontal disease
lack of purulence
impaired wound healing, with late separation of umbilical cord

persistent leukocytosis

How well did you know this?

Not at all

Perfectly

sertoli cells secrete…

AMH

leydig cells secrete…

testosterone

absence of Sertoli cells only

internal female + male

external male

isosorbide dinitrate pharmacokinetics

high 1st pass metabolism

requires higher dosing

twisting injury or blow to lateral knee while foot is planted

MCL injury

valgus stress injury

MCL injury

laxity of knee or medial joint line test via gentle press against lateral knee while lower leg is kept stationary

heteroplasmy

diff mitochondrial genomes within a single cell

mitochondrial encephalomyopathy

neuromuscular lesions ragged skeletal muscle fibers lactic acidosis

epiglottitis

H flu type B swollen, red epiglottis ("thumbprint sign"), inspiratory stridor, dyspnea, severe agitation

major virulence factor of H flu B

polysaccharide capsule ``` polyribosylribitol phosphate (PRP) protects against phagocytosis and complement-mediated lysis ```

PCOS tx

weight loss oral contraceptives tx infertility - clomiphene = selective estrogen receptor modulator

major depressive disorder tx

SSRI | block serotonin transporter

fructose 2,6 bisphosphate

enzyme = PFK-2 + by insulin + glycolysis (+PFK1) - gluconeogenesis (- fructose 1,6 bisphosphetase) - ala --> glucose

cephalosporins MOA

irreversible binding to PBPs (transpeptidases)

cephalosporin resistance

alter PB protein structure

superior vena cava syndrome

facial edema, plethora, venous distension distal to obstruction, tumor obstructing SVC cerebral edema, ICP, dilated collateral veins lung cancer non-hodgkin lymphoma

lactose intolerance

- pH stool + breath hydrogen content + stool osmolality 2/2 infection, inflammation

irreversible inhibitor COX-1 & COX-2 via acetylation

aspirin

myocyte ischemia electrolyte changes

+ intracellular Na, Ca + intramitochondrial Ca - K due to ion pump failure (Na/K) cellular swelling

dx liver functionality

prothromin time, bilirubin, albumin, cholesterol

dx structural integrity & cellular intactness of liver

transaminases

dx biliary tract

alk phos | y-glutamyl transferase (more specific)

normal alveolar pO2

104 between trachea 150 and venous blood 40

normal alveolar pCO2

40 between tracheal 0 and venous blood 45

equilibrium of O2 & CO2 limitation

perfusion limited

diffusion limited O2 equilibrium

emphysema pulmonary fibrosis exercise

AIN

IgE mediated hypersensitivity or cell mediated (IV) rxn renal interstitium interstitial edema, leukocyte infiltration + eosinophils eosinophiluria

erythropoiesis stimulating agents

EPO tx anemia of chronic kidney disease

ESA ADRs

thromboembolic events + blood viscosity hypertension