SECRETS Endo - Basics

Question 1

steroid hormones MoA

Answer 1

lipophilic - diffuse across membrane to bind cytosolic or nuclear receptors

delayed onset of action

Question 2

peptide hormones MoA

Answer 2

cell surface receptors

Question 3

tyrosine kinase receptors + examples

Answer 3

peptide hormone binds extracellular domain

promote autophosphorylation

phosphorylation of downstream target proteins

ex. insulin, growth factors
growth hormone, prolactin, cytokines (receptor-linked kinases)

Question 4

g-protein coupled receptors

Answer 4

aby-subunit complex exchanges GDP for GTP

a-subunit + by-subunit

activate/inhibit enzymes & ion channels

ex. peptides, NTs, PGs

Question 5

ligand gated ion channel

Answer 5

influx/efflux of ions

ex. NTs, aas
nicotinic receptor at NMJ – Ach, Na+ ions

Question 6

endocrine secretions

Answer 6

far away targets

carried in blood

Question 7

paracrine secretions

Answer 7

adjacent cells/tissues

Question 8

autocrine secretions

Answer 8

same cell

Question 9

neuroendocrine secretions

Answer 9

peptides released from specialized neurons

ex. hypothalamic peptides