UWORLD Cardio Pharm 3/14c

Question 1

Nitroglycerin LV EDP effect

Answer 1

-

Question 2

Nitroglycerin peripheral venous capacitance effect

Answer 2

+

Question 3

nitroglycerin SVR effect

Answer 3

-

Question 4

cilostazol

Answer 4

phosphodiesterase inhibitor –> inhibit platelet activation/aggregation
vasodilator

Question 5

cilostazol indications

Answer 5

PAD

Question 6

abciximab

Answer 6

monoclonal antibody to GP IIb/IIIa receptor

Question 7

argatroban

Answer 7

direct thrombin inhibitor

Question 8

argatroban indication

Answer 8

heparin-induced thrombocytopenia

Question 9

blanching of vein from NE infusion

Answer 9

NE extravasation

intense a1 mediated vasoconstriction –> local tissue necrosis

Question 10

NE extravasation tx

Answer 10

phentolamine

a1 antagonist = vasodilation

Question 11

TCA overdose sx

Answer 11

delirium, seizures
arrhythmias, conduction delays
sever hypotension
anticholinergic tox = hyperthermia, flushing, dry mouth, urinary retention

Question 12

TCA overdose MoA

Answer 12

block cardiac fast Na channels

inhibit muscarinic acetylcholine, histamine, a-1 receptors

Question 13

TCA overdose w/ widened QRS & ventricular arrhythmias - tx?

Answer 13

sodium bicarbonate

increase serum pH
increase extracellular Na concentration

Question 14

drug ADR = muscle toxicity

Answer 14

statins

fibrates