Urogenital Embryology Flashcards

1
Q

What are the three pre- kidneys that develop prior to the actual kidney.

And what weeks do each form?

A

Pronephros - week 4 - cervical region

Mesonephros - week 5 - thoracic region

Metanephros - End of week 5 - pelvic region

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2
Q

During mesonephros phase, excertory ducts form which join into a structure that has also formed. this other structure will remain and be important in the genital formation in males, what is it?

A

Mesonephric duct

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3
Q

The Metanerphros is formed by two distinct parts, what are they?

A

Ureteric Bud

Metanephric Cap/ Mesenchyme

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4
Q

At the bottom of the mid-gut is the ‘Drain’ which will eventually split into two, what is it called?

A

Cloaca

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5
Q

What week do the kidneys become functional?

A

Week 11/ 12

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6
Q

What creates the divide in the cloaca?

A

Urorectum Septal

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7
Q

What are the two areas that are created by the urorectum septal?

A

Urogenital sinus

rectum/ anal canal

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8
Q

What week does the urorectum septal occur?

A

week 4 - 7

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9
Q

Where does the bladder develop from?

what part does not form from here?

A

Cranial section of the urogenital sinus.

trigone region does not form from here.

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10
Q

What are the two duct systems present in the fetus - both male and female to begin with.

A

mesonephric duct

Paramesonephric duct

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11
Q

Where to the premordial germ cells derive from?

A

Epiblast

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12
Q

What cells make AMH?

A

Sertoli cells

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13
Q

When does the external genitalia start to develop?

A

week 3

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14
Q

What action does testosterone have on the genital tubercle?

A

promotes it to elongate into a phallus

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15
Q

What structure guides the gonads down through the inguinal canal?

A

Gubernaculum

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16
Q

The outgrowth of the phallus in males is dependent on what?

A

Testosterone

17
Q

The genital tubercle elongates to form the penis and genital swelling enlarge to form scrotal pouches, what are these dependent on for formation?

A

Dihydrotestosterone

18
Q

When does testicular descent occur?

A

Between 10th week

19
Q

What are the three stages of testes decent?

A

Regress of the cranial suspensory ligament at the cranial end of the testes

Transabdominal descent

Trans-inguinal decent - via the gubernaculum

20
Q

When does the final stage of testicular descent occur?

A

In final weeks of pregnancy

21
Q

What structures does the cloaca form?

A

Anus

Urethra

22
Q

What do the urethral folds become?

A

Male: Scrotal Raphe & ventral of penis

Females: Labia minora

23
Q

What do the genital swellings become?

A

Female: Labia Majora

Male: Scrotum

24
Q

What causes enlargement of the Gabernaculum and when does it occur?

A

INSL-3 and AMH

weeks 8-15

25
Q

What causes the gabernaculum to start to decent? and when does it occur?

A

Testosterone

Weeks 28-38