Unit 3: K46.Sulfa Quinolones

Question 1

Sulfonamides and trimethorprim MOA

Answer 1

Blocking folate synthesis. Sulfonamides and trimethoprim block two different steps. The combo is bactericidal and powerful.

Question 2

Bactrim = _____ + ______

Answer 2

Sulfamethoxazole + Trimethoprim

Question 3

Issue with sulfa medicines

Answer 3

Many patients develop allergies

Question 4

Bactrim can cause ____

Answer 4

Photosensitivity

Question 5

Sulfonamides are rarely used as _____ ______

Answer 5

Single agents

Question 6

Sulfasalazine is often used in…

Answer 6

Ulcerative colitis
Enteritis
Inflammatory bowel disease

Question 7

Sodium sulfacetamide is used as _____

Answer 7

Eye drops or ointment for bacterial conjunctivitis or adjunctive treatment for trachoma

Question 8

Silver sulfadiazine is used for ____

Answer 8

Infection prevention in burn wounds

Question 9

Trimethoprim is rarely used alone, but can be for ___

Answer 9

UTIs

Question 10

Trimethoprim-sulfamethoxazole TOXICITIES

Answer 10

Rash, fever, bone marrow suppression, nephrotoxocity

Question 11

LIST Fluoroquinolones

Answer 11

First one: ciprofloxacin

Respiratory options: gemifloxacin, levofloxacin, moxifloxacin

Question 12

Ciprofloxacin treats…

Answer 12

UTIs and ciprofloxacin-sensitive pseudomonas

Question 13

Fluorooquinolone MOA

Answer 13

Block enzymes, thus preventing DNA replication and bacterial multiplication

Question 14

Ciprofloxacin has almost no activity against ______ bacteria

Answer 14

GRAM+

Question 15

Moxifloxacin aka

Answer 15

Avelox

Question 16

Best fluoroquinolone for GRAM- infections

Answer 16

Ciprofloxacin

Question 17

Drug of choice for anthrax

Answer 17

Ciprofloxacin

Question 18

Gonorrhea is quickly developing resistance. So don’t use _____ or ______

Answer 18

Ciprofloxacin or Levofloxacin

Question 19

For some kinds of pneumonia, azithromycin is the drug of choice. If pt cannot take it, you can use ______

Answer 19

Respiratory fluoroquinolones

Question 20

Black box warnings for fluoroquinolones

Answer 20

Mental health side effects
Neuropathy (possibly irreversible)
Hypoglycemia and coma 
Tendonitis
Avoid in patients who are at risk for aortic aneurysm (e.g. PAD, HTN, Maegan syndrome, elderly people)

Also associated with C. Diff and prolonged QT syndrome