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NURS 804: Pharmacology > Unit 10: HPA Endocrine Meds > Flashcards

Unit 10: HPA Endocrine Meds Flashcards

1
Q

On what does TSH act?

A

thyroid

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2
Q

On what do LH and FSH act?

A

ovaries

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3
Q

On what does ACTH act?

A

adrenals

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4
Q

On what does GH act?

A

bone and soft tissues

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5
Q

What is GHRH?

A

growth hormone releasing hormone

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6
Q

What is TRH?

A

thyroid releasing hormone

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7
Q

What is CRH?

A

corticotropin-releasing hormone

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8
Q

What is GnRH?

A

Gonadotropin-releasing hormone

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9
Q

Basic definition of Pan Hypopitiuitism

A

2+ hormones secreted by the PITUITARY are not being made

a collection of many disorders

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10
Q

Who manages Pan Hypopituitism?

A

endocrinology

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11
Q

When to suspect Pan Hypopituitism?

A

when a patient has deficiencies of more than one hypothalamic hormone

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12
Q

Treatment of Pan Hypopituitism

A

replacement medications for deficient hormones

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13
Q

What is the typical cause of Pan Hyperpituitism?

A

tumor

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14
Q

When to suspect Pan Hyperpituitism?

A

when a patient has symptoms and lab findings that suggest excess of more than one hypothalamic hormone

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15
Q

How is Pan Hyperpituitism treated?

A

usually surgery

meds can suppress hormone secretion while awaiting surgery

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16
Q

What is GH?

A

growth hormone

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17
Q

What is TSH?

A

thyrotropin

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18
Q

What is ACTH?

A

adrenocorticotropin

19
Q

What is FSH?

A

follicle-stimulating hormone

20
Q

What is LH?

A

leutenizing hormone

21
Q

Name the anterior pituitary hormones

A 
GH
TSH
ACTH
FSH
LH
22
Q

For what is GH needed?

A 
height/growing tall
brain development
strong bones
metabolism of cholesterol/lipids
muscle mass
23
Q

What drugs treat GH deficiency?

A

somatotropin

mecasermin

24
Q

For what is mecasermin used?

A

IGF-I deficiency

25
Q

What does “tropic” mean?

A

make it grow

26
Q

What is IGF-1, and what does it do?

A

insulin-like growth factor
facilitates use of glucose to grow
GH –> increases IGF-1 production in liver, bone, cartilage, muscle, kidney, other tissues

27
Q

What is pseudotumor cerebri?

A

higher pressures in the brain (increased ICP) that normalize with removal of medication that causes it

28
Q

Somatotropin can cause the increase in P450 metabolism. What does the mean for other drugs?

A

other drugs metabolized by P450 will need to be prescribed in higher doses

29
Q

For whom is somatotropin absolutely contraindicated?

A

any malignancy (somatotropin makes things grow)

30
Q

Adverse effect of mecasermin, what what to do about it?

A

hypoglycemia; give with a snack within 20 minutes of dose

31
Q

Diseases of GH excess

A

gigantism

acromegaly

32
Q

What does “statin” imply?

A

stopping something

33
Q

What does somatostatin do?

A 
inhibits paracrine factor which inhibits release of:
GH
TSH
glucagon
insulin
gastrin
34
Q

Why can’t we use somatostatin to treat GH excess?

A

the half life is too short (1-3 minutes)

35
Q

What do we use to treat GH excess?

A

octreotide (Sandostatin)

36
Q

What does octreotide do?

A

Inhibits release of GH and insulin

37
Q

For what is octreotide indicated?

A

secretory diarrhea (more fluid than PO intake)
to decrease portal pressure
symptom relief for hormone-secreting tumors (to decrease hormone secretion while awaiting surgery)

38
Q

For what is an octreotide drip used?

A

esophageal variceal bleeding

39
Q

adverse effects of octreotide

A

bradycardia, arrhythmias

abdominal cramps, nausea, flatulence, steatorrhea, large BMs

40
Q

What is pegvisomant (Somavert)?

A

GH receptor antagonist

41
Q

What does pegvisomant do/not do?

A

DOES: blocks GH action

DOES NOT: inhibit GH release

42
Q

If pegvisomant blocks GH action, what does it treat? What does it not treat?

A

acromegaly

NOT gigantism

43
Q

What is the only reported adverse effect of pegvisomant?

A

elevated LFTs

NURS 804: Pharmacology (42 decks)

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