Tricyclic Antidepressants (TCA)

Question 1

Common Facts

Answer 1

Commonly used to treat: depression, neuropathic pain, insomnia
Common adverse reaction: increased cardiovascular (CV) activity, hypotension, tachycardia, sedation, weight gain, photosensitivity, severe arrhythmias with overdose
Common auxiliary labels: avoid exposure to sunlight, may cause dizziness or drowsiness

Question 2

Mechanism of Action

Answer 2

Non-selectively inhibits reuptake of serotonin (5-HT) and norepinephrine (NE)

Question 3

Anafranil

Answer 3

Generic name: clomipramine

Tablets: 10mg, 25mg, 50mg

Question 4

Aventyl

Answer 4

Generic name: nortriptyline

Capsules: 10mg, 25mg

Question 5

Elavil

Answer 5

Generic name: amitriptyline

Tablets: 10mg, 25mg, 50mg, 75mg

Question 6

Sinequan

Answer 6

Generic name: doxepin

Capsules: 10mg, 25mg, 50mg, 75mg, 100mg, 150mg