Nitrates

Question 1

Mechanism of Action

Answer 1

Nitrates are prodrugs and will be dinitrated by the body into nitric acid used to inhibit protein kinases. Nitrates relax and dilate medium to large coronary arteries and veins

Question 2

Common Adverse Reactions

Answer 2

Headache, dizziness

Question 3

Isordil

Answer 3

Generic name: isosorbide dinitrate

Available doses and forms: 5mg, 10mg, 30mg

Question 4

Imdur

Answer 4

Generic name: Isosorbide-5-mononitrate

Available doses and forms: 60mg

Question 5

Nitro-Dur

Answer 5

Generic name: nitroglycerin
Available doses and forms: Transdermal patch: 0.2mg/h, 0.4mg/h,
0.6mg/h, 0.8mg/h
Sublingual: pumpspray, tablet
IV solution: ampoule, vial
Notes: patches are only to be worn during the day and removed for
10 hours at night