5-Alpha Reductase Inhibitors

Question 1

Common Facts

Answer 1

Common ending: -asteride
Commonly used to treat: BPH (benign prostatic hyperplasia)
Common adverse reaction: erectile dysfunction (ED)

Question 2

Mechanism of Action

Answer 2

Inhibit action of 5A reductase
5A reductase= enzymes that control production of dihydrotestosterone (DHT)
Increased testosterone levels are associated with excess growth of prostate tissue

Question 3

Notes

Answer 3

May take 6-12 months of therapeutic outcomes to be seen
Harmful to developing fetus
Avoid handling with crushed or broken tablets

Question 4

Avodart

Answer 4

Generic name: dutasteride
Capsules: 0.5mg
LU required for ODB coverage