Treponema Flashcards
Two ways of transmitting T.pallidum
Bet sexual partners
Fr mother to fetus
Etiologic agent of syphilis
Treponema pallidum
T.pallidum is A.aerobic B.microaerophilic C.aerotolerant D.facultative anaerobic
B
Which can be done to T.pallidum? A.in vitro culture B.light microscopy C.dark field microscopy D.all 3
C
Also: fluorescent antibody technique
True / False
Invasion of CNS can occur during any stage of syphilis
True
In primary syphilis, a lesion called ___ develops
Chancre
False abt chancre A.painful and hard B.no ulcer and inflammatory zone C.incubation is 3 weeks D.bilateral lymphadenopathy
A.
Painless ang chancre
In secondary syphilis, __ lesions are most common
Mucocutaneous
Characteristic penile and vaginal lesions that are similar to genital warts made by HPV
Identify
Condylomata lata
Serologic tests for syphilis may not be positive during early primary syphilis. T or F?
T
Serologic tests for syphilis are usually at their lowest titer during secondary syphilis. T or F?
F
Highest dapat
In latent syphilis, the only evidence is the __
Positive serologic test for syphilis
What is the common clinical manifestation between early neurosyphilis and late neurosyphilis?
Ocular involvement
Identify: central necrosis, deep ulcer with a gummy base
gumma
T or F: Congenital syphilis may occur only during tertiary syhilis.
False
Any stage dapat
Which is not a direct manifestation of congenital syphilis? A. mucous patches B. Hutchinson's teeth C. cerebral palsy D. perforation of palate
C
Which is false?
A. Treponemal tests are qualitative.
B. Nontreponemal tests are both qualitative and quantitative.
C. The use of one quantitative test is enough for diagnosis
D. Both types of serological test may be reactive for life
C
one is not enough
Which method measures antibody directed T.pallidum antigens? A. treponemal B. nontreponemal C. both A and B D. neither A nor B
A
Which method measures antibodies directed against a cardiolipin-lecithin cholesterol antigen? A. treponemal B. nontreponemal C. both A and B D. neither A nor B
B
T or F
In nontreponemal tests, only false positive tests may occur.
F
prozone effect may also cause false negative tests.
In diagnosing latent syphilis, which is not a criteria?
A. 3-fold increase compared to serologic titer obtained within the year preceding the evaluation
B. seroconversion
C. contact to infectious syphilis case
D. none of the above
A
4-fold dapat
T or F: Neurosyphilis may occur at any stage of syphilis
T
What is the standard serological test for CSF?
VDRL-CSF
False about Neurosyphilis diagnosis
A. CSF leukocyte count is usually high in people with neurosyphilis
B. When VRDL-CSF is reactive in the absence of contamination of the CSF with blood, the patient has neurosyphilis.
C. If VRDL-CSF is positive but there are no clinical manifestations, the patient is likely to not have neurosyphilis.
D. All are true.
C
positive VRDL-CSF –> neurosyphilis, with or without clinical manifestations.
___ is the drug of choice for primary, secondary, early latent and late latent syphilis
Benzathine Penicillin G
___ is the drug of choce for neurosyphilis
Aqueous crystalline penicillin G
What is Jarrisch-Herxheimer reaction?
self-limited reaction to anti-treponemal therapy
T or F: Jarrisch-Herxheimer reaction is caused by an allergic reaction to penicillin
F
Causative agent of YAWS
Treponema pallidum subspecies Pertenue
In early yaws, a primary papule/group of papules appear at the site of inoculation after 3 weeks of incubation. This usually becomes large and crusted. this is called:
Mother Yaw/Maman pian
secondary yaws: smaller, form around primary lesion, also called: ___
ringworm yaws
What are crab yaws?
hyperkeratotic plaques that form around palms and soles
___ yaws: ulcer with clean edges that tend to fuse to form configurate and serpinginous patterns similar to tertiary syphilis
late
another name for endemic syphilis
Bejel
causative agent of bejel
T.pallidum subspecies Endemicum
true about secondary lesions @ bejel A. painful buboes B. painless ulcers C. do not grow at all D. hyperkeratotic plaque
B
true about secondary lesions @ bejel A. gummatous ulcerations B. painless ulcers C. do not grow at all D. hyperkeratotic plaque
A
causative agent of pinta
T. carateum
false about primary stage of pinta A. 7-60 days after inoculation B. with erosion but not ulcer C. tiny red papule, becoming more infiltrated D. all of the above
B
no erosion and no ulcer
false about secondary stage of pinta
A. nontreponemal tests are not reactive in all cases
B. small scalingpapules that enlarge and coalesce
C. 5 months to 1 yr
D. all of the above
A
they are reactive to 60% of the cases
the late dyschronic stage of pinta : hyperpigmented macules, or depigmented macules resembling ___
vitiligo
Yaws, Bejel and Pinta are all what kind of treponematoses?
nonvenereal treponematoses
