Leprosy Flashcards
causative agent of leprosy
Mycobacterium leprae
another name for leprosy
Hansen’s disease
true or false: Leprosy has no acute illness
true
Which is false about M.leprae? a. Waxy coating b. able to grow in vitro c. transmission is by nasal/oral droplets & dermal inoculations d. mainly a granulomatous disease
B
lack of genes needed for independent growth; need nude mice and nine-banded armadillos for
animal models
Pick which cannot be done for diagnosis of M.leprae
A.serologic test
B.skin biopsy
C.look for clinical signs
D.test for peripheral nerve thickening and tenderness
A
identify: primary external sign of Hansen’s disease
skin lesions
true or false: Leprosy can cause body parts to fall off
false
however:
Tissues are numb –> microbial invasion –> secondary infection –> weakens the body’s defenses
Explain M.leprae’s nerve damage mechanism
entry through blood vessels–>inflammatory response –>demyelination
stain used for skin smear test (M.leprae)
Ziehl Neelsen Carbol Fuschin Stain
Which is the more severe skin lesion, tuberculoid or lepromatous?
lepromatous
Where are many erythematous macules found?
A. tuberculoid
B. lepromatous
C. both A and B
B
Where can nerve enlargement be found?
A. tuberculoid
B. lepromatous
C. both A and B
A
Where can Langerhans cells be found?
A. tuberculoid
B. lepromatous
C. both A and B
A
Where does one experience Hypergammaglobulinemia?
A. tuberculoid
B. lepromatous
C. both A and B
B
Where does one experience erythema nosodum?
A. tuberculoid
B. lepromatous
C. both A and B
B
Which classification system groups leprosy cases as paucibacillary and bacillary? A. 2009 WHO Classification System B. Ridley – Jopling System C. both of the above D. none of the above
A
Define “paucibacillary”
skin lesions with no bacilli seen in a skin smear
__= Key to Progression
Fill in the blank
late treatment
Dapsone, a drug used to treat leprosy, inhibits this substance. Identify.
dihydropteroate synthase
Dapsone inhibits ___ synthesis
nucleic acid
Rifampicin inhibits synthesis of
A. DNA
B. RNA
C. both A and B
B
False about Type 1/Borderline leprosy
A. Delayed hypersensitivity occurring at the site of
localized M. leprae antigens
B. Skin lesions appear and are erythematous
C. Peripheral nerves become tender and painful
D. Loss of nerve function is gradual
D
it can be sudden
In Type 2/Borderline Lepromatous and Lepromatous cases, What results from
immune complex deposition?
Erythema nodusum leprosum (ENL)
All of the ff are final 3 countries that have leprosy, except: A.Brazil B.Egypt C.Nepal D.Timor-Leste
b
