DNA Viruses Flashcards by Joan Ravalo

False about viral tissue tropism
A.a natural inclination or preference towards specific type of cells
B.each virus replicates within certain cells
C.specific viruses cause pathologies of different tissues
D.SARS: no tropism

Ebola dapat

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False about poliovirus
A.initially multiply in the spinal cord
B.in the brain: will destroy neurons
C.may lead to neurological signs and symptoms

GIT dapat

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Which has centripetal dist of lesions?
A.chicken pox
B.small pox
C.both A and B
D.neither A nor B

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Which has centrifugal dist of lesions?
A.chicken pox
B.small pox
C.both A and B
D.neither A nor B

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False about Adenovirus
A.Virion:Icosahedral 
B.Genome: linear dsDNA
C.With major outer capsid proteins
D.Enveloped virus

Naked dapat

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False about Adenovirus
A.naked capsid composed of subunits called capsomeres 
B.replication is at the cytoplasm
C.both A and B
D.neither A nor B

Nucleus dapat

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False about Adenovirus pathogenesis
A.Most infections caused by adenoviruses are respiratory tract infections
B.Incubation period: 6-9 days 
C.In stool: shed after viremia 
D.In urine: most infectious phase

Respiratory tract secretions dapat

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False about Adenovirus
A.Attachment via the fiber structures B.Host receptor: Coxsackie-adenovirus receptor
C.Uncoating starts at cytoplasm but does not reach nucleus
D.The virus replicates well in epithelial cells

C.Uncoating starts at cytoplasm but does not reach nucleus

It ends inside nucleus!

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False about Adenovirus pathogenesis
A.Cytopathic for human cells esp. primary kidney and continuous epithelial cells
B.CPE: marked rounding, enlargement, and aggregation of affected cells into grape-like clusters
C.Wide host range

Narrow dapat

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Conjunctivitis manifestation of adenovirus

Diffuse redness of the conjunctiva

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False about adenovirus conjunctivitis
A.Usually spreads beyond regional lymph nodes
B.Single serotype may cause different clinical diseases and more than one type may cause same clinical illness C.Most infections are mild and self-limited

Does not spread

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Inefficient assembly of virions yields eosinophilic nuclear inclusion bodies containing DNA, protein, and virions. T or F?

Basophilic dapat

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Which is not a property of Papovaviruses?
A.Small icosahedral capsid virion
B.Double-stranded linear DNA genome
C.replicated and assembled in the nucleus

Circular dapat

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Human Papilloma Virus types that are significant in the Philippines- enumerate the 2

16 & 18

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Why is HPV associated with cancer?

•

Presence of oncogenes

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Which two factors determine tissue tropism?

receptor interactions and the transcriptional machinery of the cell

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Papovaviruses encode proteins that promote cell growth by

binding to the cellular growth suppressor proteins __ and __

p53

RB (retinoblastoma)

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When a papovavirus enters a permissive cell, the ff may happen except:
A. Abortive infection
B. Persistent infection
C. Latent infection
D. No transformation of nonpermissive cells

False about Papillomaviruses
A. helical virion
B. circular double-stranded DNA genome
C. two structural proteins in structure
D. cellular histones condense DNA in virion

icosahedral dapat

False about Papillomaviruses
A. Replication occurs in the nucleus
B. Enveloped
C. Restricted host range and tissue tropism
D. Viral oncoproteins interact with cellular
tumor suppressor proteins

naked dapat

Papillomaviruses can multiply only in the
A. differentiated stratified squamous epithelium
B. differentiated stratified cuboidal epithelium
C. differentiating stratified squamous epithelium
D. differentiating stratified cuboidal epithelium

another name for common wart

(Verruca vulgaris)

another name for flat wart

(Verruca planae

HPV-7 causes these warts

Butcher’s warts

identify the clinical manifestation of Papillomavirus: Greco-Latin name meaning “pointed lump” Fleshy, moist, vascular and may grow larger

Condylomata acuminata

identify: double nucleus surrounded by an area of | unstained cytoplasm

koliocytes

Benign skin warts have the characteristic feature of | ___

hyperkeratosis

lab diagnosis of Papillomaviruses: __ of smears

Papanicolau staining

False about Polyomaviruses A.Bear no resemblance whatsoever to HPV in their ability to cause disease in humans B.Ability to grow and induce cytopathic effects in cultured cells, notably those from mice embryos C.Humans are the only natural host D.None of the above

C zoonotic dapat

``` Polyomaviruses multiply in the ff except A.respiratory tract B.liver C.kidney D.none of the above ```

Where do polyomaviruses undergo latency?

kidney

``` Which multiplies in the urinary tract? A. BK virus B. JC virus C. Both A and B D. Neither A nor B ```

``` Which multiplies in the CNS? A. BK virus B. JC virus C. Both A and B D. Neither A nor B ```

``` Which may lead to possible hemorrhagic cystitis? A. BK virus B. JC virus C. Both A and B D. Neither A nor B ```

``` Which may lead to possible progressive multifocal leukoencephalopathy? A. BK virus B. JC virus C. Both A and B D. Neither A nor B ```

What is | progressive multifocal leukoencephalopathy?

leukocytes in the focal points of the brain

``` False about Parvoviruses A.smallest of all viruses B.naked virus C.icosahedral capsid D.double stranded DNA genome ```

D single dapat

Which is false? A. Parvovirus can replicate only in the presence of another virus or helper virus. B. Parvovirus can replicate in rapidly dividing host cells with active RNA synthesis. C. Parvovirus replicates only in actively dividing cells that are in the s-phase of the cell cycle. D. No parvoviruses have yet been grown in vitro.

B DNA synthesis dapat

``` What do you call the virus that helps the parvovirus replicate? A.dependovirus B.densovirus C.either A or B D.neither A nor B ```

A densovirus infects invertebrates

Dependoviruses are not pathogenic. T or F?

identify the clinical aspect of parvoviruses characterized by maculopapular over the malar areas followed w/in 4 days by a rash on the trunk & limbs persisting 2-3 wks; Incb. Pd. 13-18 days

erythema infectiosum

``` another name for erythema infectiosum A.fifth disease B.slapped cheek syndrome C.Both A and B D.Neither A nor B ```

false about aplastic crisis (c/o parvoviruus) A.precipitated by the virus in people with chronic hemolytic anemia B. very low hemoglobin and disappearance of circulating reticulocytes C.virus replicates & damages developing platelets D.persistent infection with B19 associated with chronic anemia & lymphocytic leukemia

C normoblasts dapat