Rickettsiae

Question 1

causative agent of typhus fever

Answer 1

Rickettsia prowasekii

Question 2

during World War I, this diagnostic agglutination test for typhus was developed

Answer 2

Weil-Felix reaction

Question 3

false about Rickettsiae:

a. anaerobic
b. Gram (-) but Gram stain poorly
c. contains LPS and peptidoglycan
d. all of the above are true

Answer 3

A

aerobic sila

Question 4

false about Rickettsiae:

a. Obligate intarcellular parasites (except for Rochalimaea)
b. require growth cofactors (e.g. acetyl-CoA, NAD, ATP) provided by the cell
c. grow on artificial media & on cytoplasm of eukaryotic cells
d. all of the above are true

Answer 4

C

They do not grow on artificial media

Question 5

After transmission, Rickettsia multiplies in endothelial cells of ___

Answer 5

capillaries

Question 6

Which does not happen in pathogenesis of Rickettsiae?
A. local hypersensitivity
B. regional lymphadenopathy
C. intracellular multiplication
D. none of the above

Answer 6

D

Question 7

Rickettsia may be transmitted through these invertebrates (to humans), except
A. fleas
B. mites 
C. ticks
D. spiders

Answer 7

D

Question 8

T or F

Transmission of Rickettsiae in arthropods is transovarial.

Answer 8

T

Question 9

Another name for epidemic recrudesent typhus

Answer 9

Brill-Zinsser typhus

Question 10

Causative agent of Boutonneuse typhus
A. R.canari
B. R. akari
C. R. tsutsugamushi
D. All of the 3

Answer 10

A

Question 11

Causative agent of Rickettsial pox
A. R.canari
B. R. akari
C. R. tsutsugamushi
D. All of the 3

Answer 11

B

Question 12

Causative agent of Scrub typhus
A. R.canari
B. R. akari
C. R. tsutsugamushi
D. All of the 3

Answer 12

C

Question 13

Enumerate the scientific names of the vectors of epidemic typhus

Answer 13

Pediculus humanus corporis

Pediculus humanus capitis

Question 14

One of the symptoms of epidemic typhus is maccular rash after 4-7 days. True or false?

Answer 14

true

Question 15

This type of typhus occurs after the person recovered from epidemic typhus and reactivation of R.prowazekii which remained latent for many years

Answer 15

Brill-Zinsser typhus

Question 16

another name for endemic typhus

Answer 16

murine typhus

Question 17

causative agent of endemic typhus

Answer 17

R. typhi

Question 18

vector of endemic typhus

Answer 18

Xenopsylla cheopis

Question 19

Rocky Mountain Spotted fever is caused by __

Answer 19

R. rickettsii

Question 20

False about rash @ Rocky Mountain spotted fever
A. spread is from trunk to extremites
B. sharply defined maculopapular
C. both are true
D. both are false

Answer 20

A

baliktad

Question 21

benign febrile illness with vesicular rash resembling chicken pox

Answer 21

rickettsial pox

Question 22

vector of Rickettsial pox

Answer 22

Liponyssoides sanguineus

Question 23

reservoir host of Rickettsial pox

Answer 23

Mus musculus

Question 24

Species formerly under Rochalimaea genus are now under ___ genus

Answer 24

Bartonella

Question 25

``` Some Rickettsia species may cause eschar. Which of the ff bacteria may also cause eschar: A. Bacillus anthracis B. Yersinia pestis C. Vibrio cholerae D. Streptococcus agalactiae ```

Answer 25

A

Question 26

gold standard in diagnosing Rickettsial infection

Answer 26

culture and isolation

Question 27

PCR may be used to confirm diagnosis of ___ when infection

Answer 27

ehrlichiosis

Question 28

``` In Weil-Felix test, what strains are used to find rickettsial antibodies in patient serum? A. non-motile Shigella strains B. motile Salmonella strains C. non-motile Proteus strains D. motile Enterobacter strains ```

Answer 28

C

Question 29

Most common strain used in Weil-Felix test

Answer 29

OX 19

Question 30

In Weil-Felix test, the doctor can diagnose endemic/epidemic typhus if A. strong agglutination with OX19 and OX2 B. strong agglutination with OX 19 C. strong agglutination with OX K D. strong agglutination with OX 2

Answer 30

B

Question 31

primary reservoir of R.ricketsii

Answer 31

ticks

Question 32

mode of transmission of R.prowazekii

Answer 32

breaks in skin c/o body louse

Question 33

mode of transmission of R.typhi

Answer 33

infected flea inoculates via skin break

Question 34

Coxiella burnetii has two modes of transmission. Enumerate.

Answer 34

airborne particles from contaminated sources | + ingestion of unpasteurized milk

Question 35

How is Ehrlichia chaffeensis transmitted?

Answer 35

break in skin via infected tick

Question 36

mode of transmission of R.akari

Answer 36

mites

Question 37

mode of transmission of R.canari

Answer 37

ticks

Question 38

T or F. Squirrels are reservoir hosts of R.prowazekii

Answer 38

T

Question 39

``` Which is not a reservoir host of Coxiella burnetii? A. cattle B. sheep C. goats D. humans ```

Answer 39

D

Question 40

Coxiella burnetii causes __

Answer 40

Q fever

Question 41

What is the etiologic agent of trench fever?

Answer 41

Rochalimaea quintana OR Bartonella quintana

Question 42

What is pellosis?

Answer 42

pathological entity characterized by gross appearance of multiple cyst-like, blood-filled cavities within parenchymatous organs

Question 43

What is the etiologic agent of bacillary pellosis?

Answer 43

Rochalimaea henselae OR Bartonella henselae