Systemic Mycoses

Question 1

Etiologic agents of systemic mycoses are ___ fungi
A. unimorphic
B. dimorphic
C. multimorphic

Answer 1

B

Question 2

reproductive pattern of molds

Answer 2

sporulation

Question 3

possible causative agents of Valley Fever

Answer 3

Coccidioides immitis and Coccidioides posadasii

Question 4

gross morphology of Coccidioides at Saboraud’s Dextrose Agar

Answer 4

White to tan cotton colony

Question 5

microscopic morphology of Coccidioides at Lactophenol Cotton Blue

Answer 5

thick walled barrel shaped arthrospores

Question 6

microscopic morphology of Coccidioides @ Gomori’s methanamine silver

Answer 6

spherules with

endospores (pathognomonic of coccidioidomycosis)

Question 7

A.Thrives in Dry Soil w/ High carbon and salt content
B.Semi-Arid Relatively Hot Regions
C.Seen in the Philippines

False about Coccidioides

Answer 7

C

Question 8

Pathogenesis of Coccidioides
digging of soil –> aerosol of arthrospores –> inhaled –> become (A) –> (A) produces (B) –> (B) released in lungs

What are (A) and (B), respectively?

Answer 8

(A)spherules

(B)endospores

Question 9

victims of Coccidioides are either asymptomatic or with \_\_ infection at primary stage
A. cardiac
B. pulmonary
C. gastrointestinal
D. cutaneous

Answer 9

B

Question 10

For pulmonary coccidiomycosis, what is the best specimen to collect?

Answer 10

Sputum

Question 11

microscopic morphology of Coccidioides at KOH/Calcofluor white

Answer 11

spherules with endospores

Question 12

Skin test can be used to diagnose Coccidiomycosis. T or F?

Answer 12

T. exact positive result: redness and swelling

Question 13

Ohio Valley Fever
Darling’s Disease
Reticuloendotheliosis
Cave Disease

These all refer to ___

Answer 13

Histoplasmosis

Question 14

main difference in mycelial & yeast colonies of Histoplasma

Answer 14

mycelial: cottony
yeast: waxy

Question 15

Histoplasma capsulatum , which is of ___ shape, usually inhabits these cells.

Answer 15

fish-eye

alveolar macrophages

Question 16

habitat of Histoplasma capsulatum

Answer 16

Moist soil due to high nitrogen content supplemented

with bird/bat guano

Question 17

infective stage of Histoplasma capsulatum

Answer 17

microconidia

Question 18

Primary Acute Pulmonary Disease of Histoplasma produces a lesion quite similar to ___ of primary TB

Answer 18

Ghon’s complex

Question 19

hematogenous spread of Histoplasma produces a lesion quite similar to ___ of progressive TB

Answer 19

Miliary TB

Question 20

lesions present in African Histoplasmosis: enumerate

Answer 20

Mucocutaneous lesions (abscess formation and
ulceration)
Insidious osteolytic lesions in ribs, long bones, and
cranium

Question 21

microscopic exam of Histoplasmosis

Answer 21

Broadly attached buds on thick walled yeast cells: broad

base

Question 22

Differentiate Coccidioides fr Histoplasma, in terms of culture.

Answer 22

Histoplasma uses Glucose-Cysteine Blood Agar

Coccidioides uses Blood Agar Slants

Question 23

Gilchrist’s disease
Chicago Disease

also known as __

Answer 23

Blastomycosis

Question 24

etiologic agent of Blastomycosis

Answer 24

Blastomyces dermatitidis

Question 25

Blastomyces microscopic morphology @ LPCB

Answer 25

lollipop (very tiny conidia)

Question 26

Blastomyces microscopic morphology @ Gomori's methanamine silver stain

Answer 26

thick walled, | multinucleated, spherical yeast

Question 27

A. Dormant: warm, dry season B. Growth and sporulation: cold, wet season C. Dwells in soil with low organic matter Which is false about Blastomyces?

Answer 27

C high dapat

Question 28

When airborne Blastomyces spores are inhaled by a human, s/he can have what lesions?

Answer 28

granulomatous, suppurated lesions

Question 29

clin manif of Cutaneous Blastomycosis

Answer 29

painless, raised, verrucous lesions

Question 30

microscopic exam of Blastomyces will show

Answer 30

Broadly attached buds on thick walled yeast cells: broad | base

Question 31

``` Which is not a valid source of Blastomyces? A.Sputum B.Pus C.Exudates D.Feces ```

Answer 31

D

Question 32

Serologic tests used to diagnose most, if not all, systemic mycoses - enumerate

Answer 32

Immunodiffusion | Complement Fixation Test

Question 33

South American Blastomycosis is also known as ___ / ___

Answer 33

Paracoccidioides | Paracoccidioidal Granuloma

Question 34

Etiologic agent of South American Blastomycosis

Answer 34

Paracoccidiodes brasilienses

Question 35

microscopic exam of Paracoccidioides brasilienses in Methenamine silver stain

Answer 35

appears like a Mariner’s steering wheel

Question 36

``` P.brasilienses prefers cool, humid soil. ___ therefore have occupational risk in acquiring it. A. Agricultural Workers B. Nurses C. Fishermen D. All of the above ```

Answer 36

A

Question 37

There is no latency period for primary pulmonary infection of P.brasilienses; granulomatous lesions manifest immediately. T or F?

Answer 37

F Long latency period: may last for 10-20 years

Question 38

mucocutaneous clinical manifestation of Paracoccidioides brasilienses

Answer 38

Painful ulcerated lesion may appear on the tongue, | gums, or palate

Question 39

culture media used in diagnosis of P.brasilienses that is not usually used for diagnosis of Coccidioides, Histoplasma and Blastomycoses

Answer 39

Yeast Extract Agar

Question 40

Systemic mycoses are contagious. T or F?

Answer 40

F not contagious