Enteric Viruses

Question 1

Rotavirus is a Reovirus. What does REO mean?

Answer 1

REOVirus : - Respiratory Enteric Orphan Virus

Question 2

genome of Reovirus

Answer 2

double stranded RNA

Question 3

False about Reovirus virion
A.Two concentric helical capsid with capsomeres
B. contains several enzymes for transcription
and capping of viral RNA
C. both

Answer 3

A

icosahedral dapat

Question 4

False about Reovirus
A. no envelope
B. replication is at nucleus & virions not completely coated
C. stable to heat, 3-9pH & lipid solvents
D. inactivated by 95% ethanol, phenol, chlorine

Answer 4

B

cytoplasm dapat

Question 5

Reovirus is stable in all except
A)heat
B)95% ethanol
C)3-9 pH 
D)lipid solvents

Answer 5

B

Question 6

Rotavirus group __ : primary human pathogens

A, B, C, D

Answer 6

A

Question 7

For Rotavirus: outer capsid proteins used for serotyping

Answer 7

VP4, VP7

Question 8

protein in intermediate capsid (rota virus)

Answer 8

VP6

Question 9

protein in inner capsid (rotavirus)

Answer 9

VP2

Question 10

Mature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

Answer 10

A

Question 11

Immature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

Answer 11

B

Question 12

viral protein in Rotavirus for binding & defining P serotype

Answer 12

VP4

Question 13

viral protein in Rotavirus for defining G serotype

Answer 13

VP7

Question 14

Rotavirus attaches via VP4 to what host cell receptor?

Answer 14

sialic acid

Question 15

in rotavirus

what cleaves VP4 to VP8 and VP5?

Answer 15

Trypsin enzyme

Question 16

reduction in __ of outercapsid leads to removal of VP7. releasing double shelled virus

Answer 16

Ca

Question 17

What do VP1 and VP3 facilitate? for rotavirus
A. significant parts of central dogma
B. attachment
C. virus assembly

Answer 17

A

transcription, translation, protein syn

Question 18

Rotavirus lyses the cell. T or F?

Answer 18

T

Question 19

Most common G serotype all over the world for rotavirus

Answer 19

G1

Question 20

Most common G serotype in country for rotavirus

Answer 20

G3

Question 21

viral enterotoxin c/o rotavirus that induces diarrhea

Answer 21

non-structural protein 4

Question 22

which parts of GIT are most affected by rotavirus?

Answer 22

proximal duodenum to proximal jejunum

Question 23

which is false?
A. rotavirus only takes small inoculum to develop disease
B. rotavirus affects gastric and colonic mucosa
C. rotavirus may also cause lack of sugar degradation
D. more common during cold months

Answer 23

B

Question 24

clinical triad of rotavirus

Answer 24

fever, vomiting, diarrhea

Question 25

rotavirus has respiratory symptoms, t or f?

Answer 25

t REOvirus!! symptoms: cough, coryza

Question 26

most sensitive method of diagnosis for rotavirus

Answer 26

PCR

Question 27

Rotavirus can be cultured in media with __

Answer 27

trypsin

Question 28

vaccine for rotavirus is A.combination B.pure polysaccharide C.live attenuated

Answer 28

C given orally, too :)

Question 29

official name of norovirus

Answer 29

norwalk-like viruses

Question 30

family of norovirus

Answer 30

Caliciviridae

Question 31

``` false about norovirus A. 6 =number of genogroups @ norovirus B. genome is (+)ssRNA C. virion is icosahedral D. enveloped virus ```

Answer 31

D naked say

Question 32

defining char of norovirus surface

Answer 32

cup like depression

Question 33

non-structural protein from RNA involved in RNA transcription

Answer 33

VPg

Question 34

norovirus affects what part of GIT?

Answer 34

Proximal duodenum | proximal jejunum

Question 35

enumerate what is/are malabsorbed due to norovirus

Answer 35

fat, lactose and D-xylose

Question 36

most common clinical manifestation of norovirus

Answer 36

stomach flu

Question 37

Once you have been infected with Norovirus, you are forever immune. true or false?

Answer 37

false;no lifelong immunity

Question 38

most widely used technique to detect Caliciviruses

Answer 38

PCR

Question 39

Vaccine is available for people who wish to not get Norovirus. T or F?

Answer 39

F

Question 40

Genus of Astrovirus

Answer 40

Mamastovirus

Question 41

``` false about Astrovirus A. icosahedral virion B. single strand negative sense RNA C. no envelope D. stable in acid and resistant to heat ```

Answer 41

B positive!!

Question 42

most important capsid proteins of astrovirus

Answer 42

VP26 and VP29

Question 43

symptomatic duration for astrovirus

Answer 43

3-4 days

Question 44

most useful way of diagnosing astrovirus

Answer 44

electron microscopy

Question 45

A. orofecal transmission B. highest infection rates in summer months C. low infective dose D. symptomatic treatment False about astrovirus

Answer 45

B rainy dapat

Question 46

body's mechanism of immunity vs rotavirus

Answer 46

local intestinal IgA