Respiratory Viruses Flashcards
1
Q
family of influenza virus
A
Orthomyxoviridae
2
Q
Which influenza type is zoonotic?
A. A
B. B
C. C
A
A
3
Q
Which is true? A. All have 2 surface glycoproteins. B. All have segmented genome. C. All cause human epidemics & pandemics. D. All have matrix proteins.
A
B
Type C has 1 surface glycoprotein.
Human epidemics c/o Types A & B
Type A - matrix proteins + pandemic
4
Q
Which specific influenza virus was termed “Spanish flu” in 1918-19?
A
A(H1N1)
5
Q
Which specific influenza virus was termed “Asian flu” in 1957-58?
A
A(H2N2)
6
Q
Which specific influenza virus was termed “Hong Kong flu” in 1968-69?
A
A(H3N2)
7
Q
main mode of transmission of influenza
A
Aerosol
8
Q
enumerate the protein spikes in influenzae
A
hemagglutinin or “H” spike
neuraminidase or “N” spike
9
Q
posttransitional cleavage occurs in: A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
A
10
Q
facilitates release of virion A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
B
11
Q
promotes fusion A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
A
12
Q
prevents aggregation of virus A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
B
13
Q
cleaves sialic acid residues of mucus A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
b
14
Q
binds to receptor with sialic acid A. hemagglutinin or "H" spike B. neuraminidase or "N" spike C. both D. neither
A
A
15
Q
Minor mutations in the hemagglutinin antigen
• Makes prior immunity less effective and ensures that
enough susceptible people are available for the
survival of the virus
identify
A
antigenic drift
16
Q
Occur when two separate strains of influenza infect
the same cell simultaneously
A
antigenic shift
17
Q
may cause pandemics A. antigenic shift B. antigenic drift C. both D. neighter
A
A
18
Q
Which is not a reason for Type B's "non-pandemicity"? A.There is no known animal reservoir. B. Antigenic shifts only C. both D. neighter
A
B
drift, not shift
shift–>pandemic
19
Q
Sequence the pathogenesis of influenza:
A. secondary bacterial infection
B. impairment of ciliary clearance
C. inflammation and irritation of respi tract
D. virus binds to ciliated columnar cells
E. shedding of ciliated columnar cells
A
D E B C A
20
Q
Croup is a \_\_ complication of influenza in young children. A. neurologic B. cardiac C. gastrointestinal D. pulmonary
A
D
21
Q
Reye's syndrome is a complication of influenza @ \_\_ A. liver B. CNS C. lungs D. A and B E. B and C
A
D
22
Q
Guillan-Barre syndrome is a complication of influenza @ \_\_ A. CNS B. PNS C. Both D. Neither
A
B
23
Q
antiviral drug that is as effective as vaccine in preventing influenza
A
amantadine
24
Q
zanamivir and oseltamivir inhibit __
A
sialidase
25
rimantadine and amantadine work only for type __
A. A
B. B
C. C
A
26
enumerate components of flu vaccine
A(H1N1)
A(H3N2)
B
27
T or F
| The yearly vaccine is the activated type.
F
inactivated dapat
28
Why is the interferon important?
o Puts the infected cell into an antiviral state to prevent
| the attachment or entry of the virus
29
Which is false?
A. IgG and IgA that were produced due to a specific strain will only be protective for that strain only
B. NA antibodies more important because they can neutralize
C. both
D. neither
B
HA dapat
30
Mumps has only one serotype. T or F
T
31
Type of vaccine used to prevent mumps
live attenuated vaccine
32
subfamily of mumps virus
paramyxoviruses
33
genus of mumps virus
Rubulavirus
34
genus of measles virus
Morbilivirus
35
glycoproteins present in pneumovirus subfamily
G and F
36
glycoproteins present in morbilivirus genus
H and F
37
glycoproteins present in rubula virus & paramyxovirus
HN & F
38
Which is true?
A. Mumps virus are shed in the saliva therefore it is infectious even before noticeable symptoms arise.
B. All mumps cases involve swelling.
C. Mumps is zoonotic.
D. Live attenuated vaccine is contraindicated in immunosuppressed patients, but not pregnant women.
A
30% of mumps cases: no swelling.
Man: only host.
Contraindications of vaccine: pregnant women & immunosuppressed people.
39
Most common site of growth for mumps
salivary gland
40
```
Which is not a local invader?
A.corona virus
B.rhinovirus
C.adenovirus
D.measles
```
D
41
```
Which is not a systemic invader?
A.polio virus
B.Epstein-Barr virus
C.adenovirus
D.measles
```
C
42
```
most common cause of the common cold
A.corona virus
B.rhinovirus
C.adenovirus
D.measles
```
B
43
```
False about Parainfluenza virus
A. Spherical or pleomorphic
B. Naked virus
C. Unsegmented genome
D. Negative sense, helical ss RNA
```
B
enveloped dapat
44
False about parainfluenza virus
A.Labile, but survive on surfaces for several hours
B.Resistant to destruction by soap and water, and disinfectants
C.Hemadsorbing virus
D.Antigenically stable
B
Susceptible
45
substance responsible for formation of mRNA
| and protein synthesis
• RNA-dependent RNA polymerase
46
How is parainfluenza virus transmitted?
large droplets, aerosols and fomites
47
croup is also known as __
acute parainfluenza virus laryngotracheobronchitis
48
sporadic cases are caused by
A. PIV 1
B. PIV 2
C. PIV 3
C
49
Which is not a usual diagnostic method for parainfluenza?
A.Antigen Detection in nasopharyngeal secretions
B.Viral culture
C.Serology
D.Animal inoculation
E.DNA Amplification
D
50
most sensitive method for detecting parainfluenza
E
51
```
false about respiratory syncytial virus
A.Enveloped virus
B.Spherical or pleomorphic
C.Single stranded negative sense DNA
D.None of the above
```
C
RNA dapat
52
Enumerate the envelope glycoproteins of RSV. Which determines subgroups?
F and G
| G determines subgroups
53
Which glycoprotein is in charge of viral attachment?
G protein
54
Which glycoprotein is in charge of viral fusion with cell membrane?
F protein
55
```
Which is not part of RSV pathophysio?
A)Decreased mucin secretion
B)Cell necrosis within mucosa ==>sloughing
C)Obstruction of lumina-debris, mucin
D)Peribronchial lymphocytic infiltration
```
A
increased dapat. kaya magiging mucosal edema
56
__ response in some people is linked to airway hyperreactivity
IgE
57
main modes of transmission for RSV?
droplets, fingers, fomites
58
all are radiologic features of RSV bronchiolitis except
A.Atelectasis
B.Hypoinflation
C.Streaking
D.Perihilar infiltrates esp. right middle or upper lobes
B
hyperinflation dapat
59
cytopathic effect manifestation of RSV
multinucleated giant cells
60
IDENTIFY
| synthetic guanosine analogue, given as an aerosol,
Ribavirin
61
immunoprophylaxis is passive immunization, T or F?
T
