Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PH 152 > Herpesviridae > Flashcards

Herpesviridae Flashcards

0
Q

Enumerate the members of Alphaherpesvirinae.Where does their latency happen?

A

HSV1,HSV2,VSV/HSV3

Neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q 
Which is not a property of Herpesviridae?
A)Capsid with helical symmetry 
B)Enveloped
C)Double stranded DNA viruses 
D)Only viruses assembled in the nucleus
A

A

Icosahedral dapat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Enumerate the members of Betaherpesvirinae. What is their common feature?

A

CMV, HHV6/HHV7

long periods of growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q 
Where does CMV produce latent infection?
A.glands
B.kidneys
C.neurons
D. A and B
E. B and C
A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q 
Where do HHV6 & HHV7 produce latent infection?
A.glands
B.lymphoid tissue
C.neurons
D. A and B
E. B and C
A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Enumerate members of Gammaherpesvirinae. Where do they commence their latency?

A

Epstein-Barr Virus & Kaposi sarcoma- associated herpesvirus

Lymphoid tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

False about Herpes Simplex Virus
A. HSV1 & HSV2 have same characteristics (50-70%)
B. They antigenically cross-react with VZV
C. They are zoonotic

A

C

Humans only: natural host

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How is herpes simplex virus transmitted?

A

Spread by contact; virus is shed in saliva, tears, genital and other secretions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Is this an accurate initial pathogenesis of HSV?

spreads locally –>short-lived viraemia (spread in the bloodstream) occurs –> dissemination in the body

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where does latency of HSV exactly occur?

A

Craniospinal ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q 
Encephalitis, conjunctivitis, esophagitis,  Herpes gladiatorum & Tracheobronchitis - in what HSV can these be found?
A. HSV1
B. HSV2
C. HSV3
D. All 3
A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Meningitis, perianal herpes may be found in
A. HSV1
B. HSV2
C. Both

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Gingivostomatitis, tonsillitis, labialis, pharyngitis, genital herpes, Herpes whitlow may be found in
A. HSV1
B. HSV2
C. Both

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

• Most common manifestation of primary herpes infection

A

Acute Gingivostomatitis (‘singaw’)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Identify
• Recurrence of oral HSV
• A prodrome of tingling, warmth or itching at the site usually heralds the recurrence
• About 12 hours later, redness appears followed by papules and then vesicles

A

Herpes labialis/cold sore

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q 
Herpes simplex virus does not manifest in the:
A. eye
B. ear
C. genitals
D. brain
A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IV acyclovir is given in all cases
of suspected HSE before lab results are available.
True or False?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

identify the HSV manifestation
arises from implantation of the virus
into the skin, typically affects the fingers

A

herpes whitlow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q 
Which diagnostic method can distinguish between HSV and VSV?
A. Electron microscopy of vesicle fluid 
B. Immunofluorescence of skin scrapings 
C. Both
D. Neither
A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q 
Method used used routinely for diagnosis of herpes simplex encephalitis
A. Electron microscopy of vesicle fluid 
B. Immunofluorescence of skin scrapings 
C. PCR
D. All 3
A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

identify CPE of herpes virus

A

typical ballooning of cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q 
Acyclovir & Valacyclovir directly inhibit synthesis of \_\_
A. DNA
B. RNA
C. Protein
D. Peplomers
A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

recurrence of chickenpox is called __

A

Shingles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How does VZV enter the body? Where does it go after?

A

respiratory system then lymphoid tissue

24
Latency of VSV is in __
cerebral of posterior root ganglia
25
* Incubation period: 14-21 days * self-limiting * Fever, lymphadenopathy, widespread of vesicular rash identify the VSV clinical manif
varicella
26
false about Shingles A. Mainly affect a single dermatome of the skin B. Any age but mostly in patients more than 50 year old C. Latent virus reactivates in a motor ganglion and tracks motor the sensory nerve to the appropriate segment D. Characteristic eruption of vesicles in the dermatome; often accompanied by intensive pain which may last for months
C sensory, not motor
27
In serology, presence of __ confirms past infection and immunity
VZV IgG
28
in serology, presence of __ confirms recent primary infection
IgM
29
What is used to prevent development of the illness in patients exposed to varicella?
ϒ-globulin of high varicella-zoster virus antibody titer
30
``` false about Acyclovir in VSV treatment A. Prevent development of systemic disease in varicellainfected immunosuppressed patients B. Halt progression of zoster in adults C. Prevents postherpic neuralgia ```
C
31
``` Vaccine of VSV is __ A. live attenuated B. conjugated C. killed D. pure polysaccharide ```
A
32
Reactivation of CMV can lead to vertical transmission. T or F?
T
33
``` Which is not a way to transmit CMV? A.sexual B.perinatal C.postnatal D.arthropod-borne ```
D
34
Congenital infection of CMV may result in __
cytomegalic inclusion disease
35
False about Congenital CMV A)2nd most common cause of mental handicap after Down's syndrome B) Transmission to the fetus may occur following primary or recurrent CMV infection (40% chance) C) May be transmitted to the fetus during primary stage of pregnancy only D) No evidence of teratogenicity
C all stages possible
36
For CMV, __ is regarded as gold standard but requires up to 4 weeks for result
Conventional cell culture
37
``` Which body fluids manifest (+) for neonates with CMV? A. urine and saliva B. blood and saliva C. urine and blood D. urine,blood and saliva ```
A
38
``` Which body fluids manifest (+) for adults with CMV? A. urine and saliva B. blood and saliva C. urine and blood D. urine,blood and saliva ```
C
39
``` Which body fluids manifest (+) for pregnant women with CMV? A. urine and saliva B. blood and saliva C. urine and blood D. none of the 3 ```
D serology only: igM and igG
40
diagnostic test routinely used for the rapid diagnosis of CMV infection in immunocompromised patients
pp65 CMV antigenaemia test
41
in detecting CMV, DEAFF test can provide a result in 24-48 hours. what does DEAFF mean?
(Detection of Early Antigen Fluorescent | Foci)
42
Pure polysaccharide vaccine is available in CMV prevention. T or F
F no vaccine available
43
False about Epstein-Barr virus A.Membrane is derived by budding of immature particles through cell membrane and is required for infectivity B.Viral genome integrates into the cellular DNA C.Viral genome forms circular episomes which reside in the nucleus D.All are false.
B
44
Epstein-Barr virus cannot be transmitted through kissing. True or False?
False
45
False about EBV pathogenesis A. Once infected, a lifelong carrier state ensues. B. EBV is able to immortalize T-lymphocytes in vitro and in vivo C. EBV is associated with several very different diseases where it may act directly or one of several co-factors D. The disease is kept at bay by immune defenses.
B B-lymphocytes dapat
46
``` Epstein-Barr virus is associated with the ff except A. infectious mononucleosis B. Burkitt's lymphoma C. genital warts D. nasopharyngeal carcinoma ```
C
47
False about EBV infectious mononucleosis A. Usually self-limited B. consists of fever, lymphadenopathy, and splenomegaly C. Diagnosis of IM – heterophil antibody test, detection of EBV IgG D. No specific treatment
C IgM, not IgG
48
False about Burkitt's lymphoma A.Does not respond favorably to chemotherapy B.Multiple copies of EBV genome and some EBV antigens are found in BL cells C.Patients with BV have high titers of antibodies against various EBV antigens
A
49
False about nasopharygeal carcinoma A.Malignant tumor of the ciliated columnar epithelium of the nasopharynx B.There is a number of environmental and genetic cofactors C.Usually presents late and thus prognosis is poor
A squamous
50
occurs exclusively in males who inherited a defective gene in the X-chromosome (XY chromosome for men); accounts for half of the fatal cases of EBV IM
Ducan X-linked lymphoproliferative syndrome
51
False about diagnosis of Burkitt's lymphoma A.Tumor can be stained with antigens to lambda light chains B.Reveals a monoclonal tumor of B-cell origin C.Cells express IgM at the cell surface D.None of the above
A antibodies dapat
52
False about EBV vaccination A.Vaccine against EBV prevents primary EBV infection; should be able to control BL and NPC B. Must be given early in life C. Useful in seronegative organ transplant recipients & those developing severe IM D. Vaccine should preferably be a live vaccine
D subunit vaccine dapat; live vaccine - tumorigenic
53
main target of HHV6 and HHV7 A. NK cell B. B cell C. T cell
C
54
Which is false? A. HHV-6 & HHV-7 infection are acquired rapidly after when the effect of maternal antibody wears off B. HHV-6 & HHV-7 remain latent in the body after primary infection and reactivates from time to time C. HHV-6/HHV-7 are transmitted sexually
C Transmitted mainly through contact with saliva and breastfeeding
55
Identify the HHV6 clinical manifestation o Most cases occur in infants 4 months old – 2 years o Spiking fever over a period of 2 days followed by a mild rash; fever is high enough to cause febrile convulsions
Roseola Infantum
56
main diagnostic method for HHV-6 & HHV-7
Serology
57
HHV-8 DNA is found in almost 100% of __cases
Kaposi’s sarcoma | KS

PH 152 (47 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions