Treatment Of Gout (78)

Question 1

Adenosine turns into

Answer 1

Inosine into hypoxathine

Question 2

Guanosine turns into

Answer 2

Guanine

Question 3

Hypoxathine and guanine turn into

Answer 3

Xanthine using xanthine oxidase

Question 4

Xanthine turns into

Answer 4

Uric acid using xanthine oxidase

Question 5

Uric acid accumulation creates

Answer 5

Gout

Question 6

Hyperuricemia risk factors

Answer 6

-high purine diet
-alcohol
-high fructose drinks

Question 7

Allopurinol

Answer 7

Prevents attacks
-reduces production of Uric acid

Question 8

Colchicine

Answer 8

Used for acute attacks
-reduce inflammatory response to the deposits of urate crystals

Question 9

Probenecid or sulfinpyrazone

Answer 9

Increase excretion of Uric acid in urine

Question 10

Allopurinol inhibits

Answer 10

Xanthine oxidase inhibitor

Question 11

Rheumatoid arthritis onset

Answer 11

Systemic disease across the lifespan

Question 12

Rheumatoid arthritis

Answer 12

Auto immune and inflammatory disorder
-attack synovium
-joint swelling, pain, systemic symptoms
-eventual fusing of bones

Question 13

DMARDs

Answer 13

Disease modifying anti rheumatic drugs

Question 14

DMARDs do what four things

Answer 14

-decrease pain and inflammation
-reduce or prevent joint damage and bone erosion
-slow speed and spread of disease
-preserve joint function

Question 15

DMARDs are also used in what other inflammatory conditions

Answer 15

Chrohns disease, ankylosing spondylitis, systemic lupus erythematosus

Question 16

DMARDs can be

Answer 16

Traditional or biological

Question 17

Traditional DMARDs

Answer 17

Methotrexate
-alone or in combination with other drugs

Question 18

Biologic DMARDs

Answer 18

Protein drugs against inflammatory mediators

Question 19

Biologics: infliximab, adalimumab

Answer 19

Atibody against TNFa (A cytokine)

Question 20

Etanercept

Answer 20

Receptor for TNF a

Question 21

Etanercept

Answer 21

Receptor for TNF a