Pituitary Related Drugs (62)

Question 1

Two major uses of pituitary related drugs

Answer 1

-replacement therapy in hormone DEFICIENCY

-therapy to produce a specific response when a hormone EXCESS is present

Question 2

Anterior pituitary agents (2)

Answer 2

-somatropin
-octreotide

Question 3

Posterior pituitary agents (1)

Answer 3

Vasopressin

Question 4

GH deficiency

Answer 4

-paediatric short stature
-adult muscle mass loss

Question 5

Somatropin

Answer 5

Recombinant GH
-peptide
-SC daily

Question 6

Somatropin in peds

Answer 6

Stimulate skeletal growth

Question 7

Somatropin in adults

Answer 7

Increase lean muscle mass, decrease adipose mass

Question 8

Gigantism

Answer 8

-GH excess in childhood (7to9ft)
-body proportions are normal
-headaches, profuse sweating, soft tissue swelling, cardiomegaly, hypertension, arthralgias, diabetes

Question 9

Acromegaly

Answer 9

GH excess in adults
-course facial features, large hands and feet
-headache, profuse sweating, soft tissue swelling, cardiomegaly, hypertension, arthralgias, diabetes

Question 10

Treatment options for acromegaly

Answer 10

Surgery, radiation, drugs

Question 11

Octreotide

Answer 11

GH excess
-mimics somatostatin
-inhibit GF release
-SC or IM, daily/depot

Question 12

Diabetes insipidus

Answer 12

Production of large volume of dilute urine
-deficit of vasopressin

Question 13

Vasopressin

Answer 13

Increases water reabsorption from kidney collecting ducts

Question 14

Central diabetes insipidus

Answer 14

-due to Brain surgery and head trauma
-severity depends on how much vasopressin is released

Question 15

Vasopressin and Desmopressin

Answer 15

Both used in treatment of diabetes insipidus
-reduces urinary output and severe thirst

Question 16

Desmopressin

Answer 16

Used for nocturnal enuresis (bed wetting)
-PO

Question 17

Between vasopressin and Desmopressin which is better for longer action?

Answer 17

Desmopressin
-no vasoncstrictor activity

Question 18

Water intoxication and Desmopressin/vasopressin

Answer 18

Causes hyponatremia or low blood sodium
-drowsiness, headache, light headedness, SOB

Question 19

Desmopressin is also useful for

Answer 19

Clotting disorders
-hemophilia A
-von willebrands disease

Question 20

Vasoconstrictor effect of vasopressin

Answer 20

-enhanced CPR during CA
-treatment of various types of bleeding, especially GI bleeding