Immunosuppressant Drugs (69) Flashcards
Errors of the immune systems causes, and is sometimes referred to as
Sometimes can attack itself
-autoimmune diseases, or immune mediated diseases
Immune system is responsible for
Rejection of donated organs and anaphylactic reactions
Immunosuppressants
Drugs that decrease or prevent an immune response thus suppressing the immune system
Immunosuppressants are used to prevent/treat
Rejection of transplanted organs and autoimmune diseases
Immunosuppressants action
-reduce lymphocyte cell division
-pharmacologically immunocompromised state
What is a Pharmacologically immunocompromised state
Reduced or little specific immune protection due to drugs
Three examples of immunosuppressants
Glucocorticoids
Cyclosporine
Tacrolimus
Glucocorticoids
Cyclosporine
Tacrolimus
Examples of how immunosuppressants work
-drugs that inhibit cytokine production/action
-block cytokine receptors on immune cells
-drugs that inhibit DNA/RNA synthesis
Examples of when to use immunosuppressants
-rheumatoid arthritis
-prevention of organ rejection
-crohns disease
What are the cytokine production inhibitors
-cyclosporine
-Tacrolimus
Both cyclosporine and Tacrolimus…
Reduce interleukin-2 synthesis
Cytokines are crucial in
T lymphocyte proliferation and activity
Cytokine production inhibitors will cause..
Reduced T lymphocyte number/activity
Cyclosporine
Cytokine production inhibitor
Cyclosporine is used for
Prevention of kidney, liver, heart and bone marrow transplant rejection
-may be other autoimmune disorders
Tacrolimus
Cytokine production inhibitor
Tacrolimus
Used for organ rejection prevention in liver and kidney transplant
-active rheumatoid arthritis
Adverse effects of cyclosporine
-kidney damage (nephrotoxity)
-high BP
-tremors
-hirsutism (male like hair pattern)
What do you treat high blood pressure with
Antihypertensives
What is hirstutism
Excessive male like hair pattern
Drugs that inhibit cytokine gene expression
Glucocorticoids
(Coticoids, corticosteroids, glucocorticosteroids)
