Immunosuppressant Drugs (69)

Question 1

Errors of the immune systems causes, and is sometimes referred to as

Answer 1

Sometimes can attack itself
-autoimmune diseases, or immune mediated diseases

Question 2

Immune system is responsible for

Answer 2

Rejection of donated organs and anaphylactic reactions

Question 3

Immunosuppressants

Answer 3

Drugs that decrease or prevent an immune response thus suppressing the immune system

Question 4

Immunosuppressants are used to prevent/treat

Answer 4

Rejection of transplanted organs and autoimmune diseases

Question 5

Immunosuppressants action

Answer 5

-reduce lymphocyte cell division
-pharmacologically immunocompromised state

Question 6

What is a Pharmacologically immunocompromised state

Answer 6

Reduced or little specific immune protection due to drugs

Question 7

Three examples of immunosuppressants

Answer 7

Glucocorticoids
Cyclosporine
Tacrolimus

Question 8

Glucocorticoids

Question 9

Cyclosporine

Question 10

Tacrolimus

Question 11

Examples of how immunosuppressants work

Answer 11

-drugs that inhibit cytokine production/action
-block cytokine receptors on immune cells
-drugs that inhibit DNA/RNA synthesis

Question 12

Examples of when to use immunosuppressants

Answer 12

-rheumatoid arthritis
-prevention of organ rejection
-crohns disease

Question 13

What are the cytokine production inhibitors

Answer 13

-cyclosporine
-Tacrolimus

Question 14

Both cyclosporine and Tacrolimus…

Answer 14

Reduce interleukin-2 synthesis

Question 15

Cytokines are crucial in

Answer 15

T lymphocyte proliferation and activity

Question 16

Cytokine production inhibitors will cause..

Answer 16

Reduced T lymphocyte number/activity

Question 17

Cyclosporine

Answer 17

Cytokine production inhibitor

Question 18

Cyclosporine is used for

Answer 18

Prevention of kidney, liver, heart and bone marrow transplant rejection
-may be other autoimmune disorders

Question 19

Tacrolimus

Answer 19

Cytokine production inhibitor

Question 20

Tacrolimus

Answer 20

Used for organ rejection prevention in liver and kidney transplant
-active rheumatoid arthritis

Question 21

Adverse effects of cyclosporine

Answer 21

-kidney damage (nephrotoxity)
-high BP
-tremors
-hirsutism (male like hair pattern)

Question 22

What do you treat high blood pressure with

Answer 22

Antihypertensives

Question 23

What is hirstutism

Answer 23

Excessive male like hair pattern

Question 24

Drugs that inhibit cytokine gene expression

Answer 24

Glucocorticoids
(Coticoids, corticosteroids, glucocorticosteroids)

Question 25

Glucocorticoids mimic

Answer 25

Cortisol, the most important endogenous glucocorticoid

Question 26

Prednisone

Question 27

What two drugs inhibit RNA and DNA synthesis

Answer 27

-azathioprine
-mycophenolate mofetil

Question 28

Azathioprine

Answer 28

Prevent transplant rejection and rheumatoid arthritis

Question 29

Mycophenolate mofetil

Answer 29

Prevent translplant rejection