Psychosis: Antipsychotic Drugs (34)

Question 1

Positive symptoms of schizophrenia

Answer 1

-delusions
-paranoia
-hallucinations
-disorganized or catatonic behaviour

Question 2

Negative symptoms of schizophrenia

Answer 2

-flat emotions
-withdrawal from social contacts, lack of speech, poor self care
-avolition

Question 3

Antipsychotics =

Answer 3

Neuroleptics

Question 4

Indications for antipsychotics

Answer 4

-serious mental illnesses (schizophrenia, bipolar disorder, autism)
-movement disorders

Question 5

Three major objective with schizophrenia drug therapy

Answer 5

-suppress acute episodes
-reduce relapse
-maintenance of the highest possible level of functioning

Question 6

Adjunctive drugs

Answer 6

Benzodiazepines and antidepressants

Question 7

Which symptoms of schizophrenia responds better to treatment

Answer 7

Positive symptoms

Question 8

First gen antispsychotics

Answer 8

Chlorpromazine

Question 9

Second gen antipsychotics

Answer 9

Clozapine

Question 10

Typical antipsychotics MOA

Answer 10

Dopamine receptor antagonists
-block receptors in CNS

Question 11

AE of typical antipsychotics

Answer 11

DA receptor antagonism
-motor disturbances

Question 12

Extrapyramidal motor disturbances

Answer 12

Early onset
-acute dystopias (muscle tension, neck, face, tongue, eyes)
-pseudoparkinsonism
-akathisia
-tar dive dyskinesia

Question 13

Extrapyramidal motor disturbances vs Extrapyramidal symptoms

Answer 13

2 terms same meaning

Question 14

Other AE of typical antipsychotics

Answer 14

-neuroleptic malignant syndrome
-therapy
-neurological
-CNS
-CV
-dermatological

Question 15

AE of typical antipsychotics: Neuroleptic malignant syndrome

Answer 15

4 to 14 days after therapy
-lead pipe rigidity
-sudden high fever
-CV problems
-may end in seizures or coma

Question 16

AE of typical antipsychotics: Therapy

Answer 16

Removal of typical antipsychotic drug
-bromocriptine

Question 17

AE of typical antipsychotics: neurological

Answer 17

Extrapyramidal motor disturbances

Question 18

AE of typical antipsychotics: other CNS

Answer 18

Sedation and delirium

Question 19

AE of typical antipsychotics: cardiovascular

Answer 19

Othrostatic hypotension, syncope, dizziness, ECG changes

Question 20

Atypical antipsychotics/second generation example

Answer 20

Clozapine

Question 21

Atypical antipsychotics

Answer 21

Newer drugs in Canada

Question 22

MOA atypical antipsychotics

Answer 22

Block 5 HT receptors
-less effect on DA
-equal efficacy to typical antipsychotics

Question 23

Clozapine AE

Answer 23

Haematological, drooling, agranulocytosis

Question 24

All antipsychotics may cause

Answer 24

Weight gain, disturbances in metabolism, extent varies with drug

Question 25

People should not take what with antipsychotics

Answer 25

Alcohol or other CNS depressants