Respiratroy Tract Drugs: Asthma And COPD (79) Flashcards
Bronchial asthma
Recurrent and reversible shortness of breath
-lung airways narrow (bronchospasms, inflammation of bronchial mucosa)
Bronchospasms are a response
To mechanicals released form immune system and secretions
Airflow limitation is caused by
Bronchospasms and inflammation
Bronchial asthma
Alveolar ducts/alveoli remain open but airflow is obstructed
-causing difficulty breathing or wheezing
Status asthmaticus
Medical emergency
-prolonged asthma attack
-does not respond to usual medical therapy
COPD
Chronic obstructive pulmonary disease
-obstruction is constantly present, but can vary in severit y
Tobacco smoke and air pollution causes
Inflammation of the airway epithelium
-release of cytokines
Chronic bronchitis is
Continous inflammation of the bronchi and bronchioles
-result of prolonged exposure to bronchial irritants
Emphysema
Air spaces enlarge as a result of the destruction of alveolar walls
-surface area is reduced
-impaired res[iration
Bronchodilator’s
-B2 adrenergic agonists
-anticholinergics
-can think derivatives
B2 adrenergic agonists
Albutamol salbutamol
Anticholinergics
Ipratropium bromide
Xanthine derivatives
Theophylline/aminophylline
Anti inflammatory drugs
-glucocorticoids
-leukotriene modifiers
Issues with inhalers
Technique
-local effect and much quicker
PO drug will interact with more
Receptors = more AE
Bronchodilator’s: B agonists are
Sympathomimetic bronchodilators
-stimulate bronchial smooth muscle b2 andrenergic receptors
Two types of smooth muscle b2 adrenergic receptor s
-short acting B agonists (SABA)
-long acting B agonists (LABA)q
Selective b2 drugs
Activate airway smooth muscle b2 adrenergic receptors
Example of selective b2 drugs
Salbutamol (SABA)
Mechanisms of action of B agonists
Dilation of airways
How do B agonists dilate airways
Activation of smooth muscle b2 receptors
Activation of smoooht muscle b2 receptors
Relax smooth muscles of the airway resulting in bronchial dilation
-increasing airflow
Indications for B agonists
-relief of bronchospasm related to asthma, COPD, other pulmonary disease
-acute asthma attacks
-repent attacks
Adverse effects of B agonists
-cardiac stimulation
-tremors
-restlessness and insomnia
Why do B agonists cause cardiac stimulation
Tachycardia
Salbutamol adverse effects
-b2 receptor effects
-decrease receptor selectivity
Salbutamol adverse effects: b2 receptor effects
Muscle tremor, CNS, anxiety, nausea
Salbutamol adverse effects: decreases receptor selectivity
Stimulates b1 adrenergic receptors in heart
Stimulation of b1 adrenergic receptors in heart causes
Increased heart rate, palpitations, chest pains, angina
Why do these adverse effects happen in salbutamol
When inhaled form is used too frequently
Adverse effects are more likely with (salbutamol)
More likely with oral preparations
Good to encourage what sort of measures for clients taking bronchodilators/B agonists
Good state of health in order to prevent, relieve or decrease symptoms of asthma/COPD
Avoid exposure to conditions that
Precipitate bronchospsms, like smoking, allergens, stress, air pollutants
What else is important for bronchodilators and B agonists
Adequate fluid intake
What therapeutic effects should we be monitoring for, when on b agonists
Decreased: dyspnea, wheezing, restlessness and anxiety
Improved: respiratory patterns, activity tolerance
Mechanism of action of anticholinergics
Anticholinergic drug binds to cell membrane blocking ilgand from binding at binding site