Antidepression (34)

Question 1

Mood

Answer 1

Sustained emotional attitude
-typically garnered through patient self report

Question 2

Affect

Answer 2

The way a patients emotional state is conveyed
-relates more to others perception of the patients emotional state and responsiveness

Question 3

Norepinephrine is a

Answer 3

Catecholamines

Question 4

Serotonin is a

Answer 4

Indolamine

Question 5

Newer generation antidepressants (3)

Answer 5

-selective serotonin reputable inhibitors
-mixed serotonin and NE reputable inhibtiors
-NE ruptake inhibitors

Question 6

TCA stands for

Answer 6

Tricyclic antidepressants

Question 7

MAOIs

Answer 7

Monoanime oxidase inhibitors

Question 8

SSRIs are the most commonly

Answer 8

Prescribed drugs for depression

Question 9

SSRIs example

Answer 9

Sertraline

Question 10

How long do SSRIs take to have effects

Answer 10

2 to 6 weeks

Question 11

SSRIs MOA

Answer 11

-selectively inhibit 5 HT reputable
-advantage over tricyclics and MAOIs

Question 12

Selectively inhibit 5 HT reputable causes (2)

Answer 12

-increased serotonin concentration in synapse
-little or no effect on NE or DA reuptake

Question 13

Advantage over tricyclics and MAOIs causes little or no effect on

Answer 13

Cardiovascular system

Question 14

Indications of SSRIs

Answer 14

-major depressive disorder
-Bipolar

Question 15

AE of SSRIs

Answer 15

-headache, nervousness, insomnia, fatigue
-nausea
-sexual dysfunction and weight gain

Question 16

Serotonin syndrome occurs within

Answer 16

2 to 72 hours

Question 17

Serontin syndrome symptoms

Answer 17

Confusion, agitation, restlessness, tachycardia, hypertension, hyperthermia, sweating, clonus, Hyperkalemia, tremor

Question 18

SNRI stands for

Answer 18

Serotonin and norepinephrine reuptake inhibitor

Question 19

Example of an SNRI

Answer 19

Venlafaxine

Question 20

SSRI and SNRI are no more effective than

Answer 20

Older TCAs and MAOIs

Question 21

SSRI and SNRI have fewer AE than

Answer 21

TCAs - Anticholinergic action
MAOIs - cheese reaction

Question 22

Tricyclic antidepressants stands for

Answer 22

TCAs

Question 23

TCAs have largely been replaced as first line drugs for depressant by

Answer 23

SSRI/SNRI

Question 24

TCAs are considered second line for

Answer 24

-clients who fail with SSRIs or other newer generation antidepressants
-adjunct therapy with newer drugs

Question 25

Indications of TCAs

Answer 25

-depression -childhood enuresis -OCD -analgesics -trigeminal neuralgia

Question 26

Examples of TCA

Answer 26

Amitriptyline

Question 27

TCAs MOA

Answer 27

Block: NE reuptake, 5 HT reuptake

Question 28

TCA also is a receptor block of

Answer 28

-mucarinic receptor -a1 adrenoceptors -H1 receptor

Question 29

Adverse effects of TCAs

Answer 29

-sedation -Anticholinergic effects -orthostatic hypotension

Question 30

TCA causes sedation due too

Answer 30

CNS H1 receptor blockade -wears off after 1-2 weeks

Question 31

TCA causes Anticholinergic effects such as

Answer 31

Blurred vision, drymouth, constipation, urinary retention, tachycardia

Question 32

TCA causes orthostatic hypotension due too

Answer 32

A1 adrenoceptor blockade

Question 33

Serious AE of TCAs

Answer 33

Cardiac dysrhythmias and seizures

Question 34

TCAs in overdose

Answer 34

Can be lethal -70 to 80% die before reaching hospital

Question 35

What is the antidote for acute toxicity in TCAs

Answer 35

There is no antidote for acute toxicity -activated charcoal decreases drug absorption -BLS -manage seizures and dysrhythmias -alkalinizing urine to speed elimination

Question 36

MAOIs are first generation drugs for

Answer 36

Depression

Question 37

MAOIs are now treatment that

Answer 37

Other drugs dont help to relieve depression

Question 38

Disadvantages of MAOIs

Answer 38

Potential to cause hypertensive crisis when taken with tyramine

Question 39

MAOIs MOA

Answer 39

Inhibit MAO enzyme and reduce breakdown of mono amines in neurones

Question 40

Inhibiting MAO enzymes located in

Answer 40

CNS and peripheral tissues

Question 41

Reduced breakdown of monoamines in neurons causes

Answer 41

Greater amounts released from neurons

Question 42

MAOIs AE

Answer 42

Orthostatic hypotension, CNS stimulation

Question 43

Food and drug interactions MAOIs

Answer 43

Ingestion of foods and drinks with tyramine may lead to hypertensive crisis

Question 44

Hypertensive crisis

Answer 44

Most serious problem with MAOIs -severe headaches, hypertension, tachycardia

Question 45

When taking MAOIs you need to avoid foods containing

Answer 45

Tyramine -aged, mature cheeses

Question 46

If switching from an SSRI to MAOI there must be

Answer 46

A 2 to 5 week wash out drug free period between SSRI and MAOI therapy

Question 47

If switching from a MAOI to a TCA or SSRI there must be

Answer 47

A 2 week wash out drug free period -also maintain diet restriction 2 weeks after MAOI cessation

Question 48

Bupropion

Answer 48

Block of DA and NE reuptake -depression

Question 49

Mirtazapine

Answer 49

Increases release of 5 HT, antagonism at certain 5 HT receptors -depression

Question 50

Vortioxetine

Answer 50

Complex modulation of 5 HT neurotransmission -depression

Question 51

Important to inform clients that it may take

Answer 51

2 to 4 weeks to see therapeutic effects

Question 52

Sedation often occcurs with __ therapy

Answer 52

Tricyclic