Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Antidepression (34) > Flashcards

Antidepression (34) Flashcards

1
Q

Mood

A

Sustained emotional attitude
-typically garnered through patient self report

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Affect

A

The way a patients emotional state is conveyed
-relates more to others perception of the patients emotional state and responsiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Norepinephrine is a

A

Catecholamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Serotonin is a

A

Indolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Newer generation antidepressants (3)

A

-selective serotonin reputable inhibitors
-mixed serotonin and NE reputable inhibtiors
-NE ruptake inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

TCA stands for

A

Tricyclic antidepressants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MAOIs

A

Monoanime oxidase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

SSRIs are the most commonly

A

Prescribed drugs for depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SSRIs example

A

Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How long do SSRIs take to have effects

A

2 to 6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SSRIs MOA

A

-selectively inhibit 5 HT reputable
-advantage over tricyclics and MAOIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Selectively inhibit 5 HT reputable causes (2)

A

-increased serotonin concentration in synapse
-little or no effect on NE or DA reuptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Advantage over tricyclics and MAOIs causes little or no effect on

A

Cardiovascular system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Indications of SSRIs

A

-major depressive disorder
-Bipolar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AE of SSRIs

A

-headache, nervousness, insomnia, fatigue
-nausea
-sexual dysfunction and weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Serotonin syndrome occurs within

A

2 to 72 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Serontin syndrome symptoms

A

Confusion, agitation, restlessness, tachycardia, hypertension, hyperthermia, sweating, clonus, Hyperkalemia, tremor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

SNRI stands for

A

Serotonin and norepinephrine reuptake inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Example of an SNRI

A

Venlafaxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

SSRI and SNRI are no more effective than

A

Older TCAs and MAOIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

SSRI and SNRI have fewer AE than

A

TCAs - Anticholinergic action
MAOIs - cheese reaction

22
Q

Tricyclic antidepressants stands for

A

TCAs

23
Q

TCAs have largely been replaced as first line drugs for depressant by

A

SSRI/SNRI

24
Q

TCAs are considered second line for

A

-clients who fail with SSRIs or other newer generation antidepressants
-adjunct therapy with newer drugs

25
Q

Indications of TCAs

A

-depression
-childhood enuresis
-OCD
-analgesics
-trigeminal neuralgia

26
Q

Examples of TCA

A

Amitriptyline

27
Q

TCAs MOA

A

Block: NE reuptake, 5 HT reuptake

28
Q

TCA also is a receptor block of

A

-mucarinic receptor
-a1 adrenoceptors
-H1 receptor

29
Q

Adverse effects of TCAs

A

-sedation
-Anticholinergic effects
-orthostatic hypotension

30
Q

TCA causes sedation due too

A

CNS H1 receptor blockade
-wears off after 1-2 weeks

31
Q

TCA causes Anticholinergic effects such as

A

Blurred vision, drymouth, constipation, urinary retention, tachycardia

32
Q

TCA causes orthostatic hypotension due too

A

A1 adrenoceptor blockade

33
Q

Serious AE of TCAs

A

Cardiac dysrhythmias and seizures

34
Q

TCAs in overdose

A

Can be lethal
-70 to 80% die before reaching hospital

35
Q

What is the antidote for acute toxicity in TCAs

A

There is no antidote for acute toxicity

-activated charcoal decreases drug absorption
-BLS
-manage seizures and dysrhythmias
-alkalinizing urine to speed elimination

36
Q

MAOIs are first generation drugs for

A

Depression

37
Q

MAOIs are now treatment that

A

Other drugs dont help to relieve depression

38
Q

Disadvantages of MAOIs

A

Potential to cause hypertensive crisis when taken with tyramine

39
Q

MAOIs MOA

A

Inhibit MAO enzyme and reduce breakdown of mono amines in neurones

40
Q

Inhibiting MAO enzymes located in

A

CNS and peripheral tissues

41
Q

Reduced breakdown of monoamines in neurons causes

A

Greater amounts released from neurons

42
Q

MAOIs AE

A

Orthostatic hypotension, CNS stimulation

43
Q

Food and drug interactions MAOIs

A

Ingestion of foods and drinks with tyramine may lead to hypertensive crisis

44
Q

Hypertensive crisis

A

Most serious problem with MAOIs
-severe headaches, hypertension, tachycardia

45
Q

When taking MAOIs you need to avoid foods containing

A

Tyramine
-aged, mature cheeses

46
Q

If switching from an SSRI to MAOI there must be

A

A 2 to 5 week wash out drug free period between SSRI and MAOI therapy

47
Q

If switching from a MAOI to a TCA or SSRI there must be

A

A 2 week wash out drug free period
-also maintain diet restriction 2 weeks after MAOI cessation

48
Q

Bupropion

A

Block of DA and NE reuptake
-depression

49
Q

Mirtazapine

A

Increases release of 5 HT, antagonism at certain 5 HT receptors
-depression

50
Q

Vortioxetine

A

Complex modulation of 5 HT neurotransmission
-depression

51
Q

Important to inform clients that it may take

A

2 to 4 weeks to see therapeutic effects

52
Q

Sedation often occcurs with __ therapy

A

Tricyclic

Pharmacology (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions