Transplantation Flashcards
Direct Recognition
Donor DCs cause T cells to proliferate
Indirect Recognition
Graft peptides make T cells proliferate in nodes
Semi-Direct Recognition
Donor APCs combine with recipient APCs
Transplant chance
= blood group+ HLA type+ sensitisation
Hyperacute Reaction
Activation of cascades
Get organomegaly, necrosis and DIC
Group+ Screen
ABO+Rh group
Blood group Abs and antiglobulin test
Crossmatching
Mix RBCs with pt plasma to see if there is a reaction
Acute Haemolytic Reaction
Hb deposited in kidneys
Coag and cytokine stimulated
Vasoconstriction, fever, pain, shock, DIC
Due to ABO incompatibility
Delayed Haemolytic Reaction
Symps= fever, jaundice, fatigue
Abs against RBC Ags made after transfusion
Increased LDH and bilirubin
Transfusion-Related Acute Lung Injury
Donor Abs to pts leucocytes
Leucocytes lodge in lung capillaries
Get hypoxemia and infiltrates
Transfusion-Associated Circulatory Overload
Symps= dyspnoea, orthopnoea, tachy, high BP, hypoxemia
Need diuretics
Febrile Non-Haemolytic Transfusion Reactions
Cytokines accumulated in storage
Get fever, shakes and tachy
