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Integrated > Blood Markers > Flashcards

Blood Markers Flashcards

1
Q

ESR

A

Measures viscosity of serum
Plasma thicker in inflam
Takes a while to resolve

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2
Q

CRP

A

Made by liver in crisis
Detects cytokines
Useful acutely

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3
Q

Ferritin

A

Goes up in inflam

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4
Q

Fibrinogen

A

Goes up in inflam

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5
Q

Albumin

A

Down in inflam

Low in cirrhosis

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6
Q

C3+C4

A

Low in inflam as used up

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7
Q

ANA Abs

A

+ve in SLE, infection and elderly

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8
Q

dsDNA

A

Raised in SLE (sometimes)

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9
Q

Rheumatoid Factor

A

Ab against FC portion of IgG

Found in RA and chronic infections

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10
Q

Anti-CCP

A

Also raised in RA

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11
Q

ANCA

A

Ab for Wegener’s granulomatosis

Cytoplasmic or perinucleur

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12
Q

MHC

A

Same as HLA
Class I on nucleated cells
Class II on B cells

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13
Q

Alkaline Phosphotase

A

Raised in biliary tract damage
Made in liver, bone, intestine and placenta
Elevated in jaundice

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14
Q

ALT+AST

A

Alanine and aspartate aminotransferase
Released in cellular damage
ALT more liver specific
Elevated in Hep

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15
Q

Bilirubin

A

Total, unconjugated or conjugated
Made from Hb
Binds to albumin in blood

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16
Q

GGT

A

Gamma glytamyl transferase

Raised in biliary tract damage

17
Q

Troponins

A

Rasied after 2 hours in MI, peak at 12, high for a week

Also raised in PE, LVF and myocarditis

18
Q

Creatinine Kinase

A

Detectable 2 hours after MI

Normal in 3 days

19
Q

Plasma Urea

A

Filtered at glomerulus
More reabsorbed at tubules if slow flow
Increased in GI bleed, trauma, AKI, obstruction

20
Q

Plasma Creatinine

A

Conc increases as GFR decreases

Amount of change important

21
Q

FBC

A

Hb conc, MCV, MCHb, WCC, platelet count

22
Q

Coag Screen

A

Prothrombin
Thrombin
APTT

23
Q

APTT

A

Prolonged in deficiency and inhibitor

Deficiency corrected by 50% normal plasma

Integrated (36 decks)

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