Immunosuppression

Question 1

Corticosteroids

Answer 1

Reduce cytokines

Get lymphopenia, less T cells

Question 2

Cytotoxic Agents

Answer 2

Get high BP, P450 induction and nephrotoxicity

For transplants and AI disorders

Question 3

Calcineurin Inhibitors

Answer 3

e.g. Ciclosporin A, tacrolimus
Prevents cytokine activation
Inhibits T cells activation and proliferation

Question 4

Sirolimus

Answer 4

Aka rapamycin
Macrolide abx
Inhibits response to IL-2

Question 5

Antimetabolites

Answer 5

Inhibits nucleotide synthesis
e.g. AZA, MMF
Impaired T+B cell DNA production
Methotrexate

Question 6

Biologic DMARDS

Answer 6

Anti-B cells
e.g. rituximab
Used for cancer, rejection, RA