Immunocompromised

Question 1

Qualitative Neutrophil Defect

Answer 1

Chemotaxis
NADPH oxidase (get s aureus as can't kill)

Question 2

Chronic Granulomatous Disease

Answer 2

X linked
Due to NADPH oxidase defect
Get osteomyelitis, IBD, pneumonia
Lots of abscesses

Question 3

Quantitative Neutrophil Defect

Answer 3

Causes= bone cancer, chemo, aplastic anaemia
Get bacterial and fungal infections (need aminoglycosides or antipseudomonas)
G-CSF can increase number from marrow

Question 4

T Cell Defect

Answer 4

Acquired= viruses+ drugs

Get weird bacteria, viurses and fungi

Question 5

Hypogammaglobulinaemias

Answer 5

Acquired= multiple myeloma, CLL, burns

Get encapulated bacteria (s pneumoniae, giardia, cryptosporidium)

Question 6

Complement Deficiency

Answer 6

Encapsulated bacterial infections (n meningitidis, s pneumoniae)

Question 7

Splenectomy

Answer 7

Less complement and Abs

Get s pneumoniae, h influenzae, n menigitidis, malaria

Question 8

B Cell Defect

Answer 8

Maternal IgG protects initially

Causes= X-LInked Agammoglobulinaemia

Question 9

Severe Combined Immunodeficiency Syndrome

Answer 9

Defects in T cells which affects B cells
Recurrent infections
Need BM transplant or gene therapy