Antifungals Flashcards
1
Q
Polyenes
A
Make pores in ergosterol
Amphoterecin (for aspergillus, candida and cryptococcus)
Nystatin (superficial candida)
2
Q
Allylamines
A
Inhibit squalene epoxidase (membrane)
Terbinafine for dermatophyte infections
3
Q
Azoles
A
Inhibit lanosterol (membrane) Very broad
4
Q
Imidazoles
A
Only systemic use
e.g. clotrimazole and ketoconazole (causes hep)
5
Q
Triazoles
A
Fluconazole for yeasts (NOT aspergillus), itraconazole and variconazole
6
Q
Echinocandins
A
Inhibits b-1,3-glucan synthase (cell wall)
e.g. anidulafungin
For aspergillus and candida
7
Q
5-Fluorocytosine
A
Inhibits RNA and DNA synthesis
Yeasts only
Suppresses marrow
