Resp Conditions Flashcards
Squamous Lung Carcinoma
Desmosomes between cells
Central
Hypercalcaemia
Smoking link
Lung Adenocarcinoma
Benign
Smoking link
Expresses TTF
Neuroendocrine Tumours
Carcinoid= bronchi, no necrosis, invades lymph, atypical has necrosis
Large Cell= smoking link, necrosis, mitosis
Small Cell= smoking link, rapid spread, secretes ACTH and CD56
Treatment for Cancers
Tyrosine kinase inhibitors (gefitinib and erotinib) ATP analogues (crizotinib)
Pleurisy
Causes= inflam, pneumonia, TB, infarct, tumour
Asbestos
Causes effusion, fibrous plaques, diffuse fibrosis and mesothelioma
Bronchitis
Viral (RSV, adeno)
Bacterial ( H influezae, S pneumoniae, croup, M pneumoniae)
Bronchiolitis
Causes= viral
Can get bronchopneumonia
Follicular or obliterary
Pneumonia
Broncho= secondary, low virulence bacteria, patchy Lobar= primary, s pneumoniae, get pleuritis Severity= CURD-65
Atypical Pneumonia
Causes= viruses, measles, m pneumoniae, chlamydia, legionella Immunosuppressed= fungal, HSV, CMV Hospital-acquired= enterobacteriacae and pseudomonas
Vasculitis
Necrotising granulomatous or Wegener’s
Goodpasture’s= glomerulonephritis, alveolar haemorrhage
Bronchiectasis
Causes= CF, tumour, SLE, RA, IBD
COPD
Chronic bronchitis= mucus gland hyperplasia, hypersecretion, chronic inflam
Emphysema= centrilobular, panlobular or paraseptal
Diffuse Alveolar Damage
Exudative as more type II pneumocytes
Acute interstitial pneumonia
Fibrosis
Idiopathic= cobblestone pleura Sarcoidosis= non-caseating granulomas, hypercalcaemia
