Transferring Information Across Membranes

Question 1

Fill in blanks:

Answer 1

Question 2

What molecule is this? What’s the red subunit? How does the mechanism work? Explain it.

Answer 2

Beta 2 Adrenergic receptor

Question 3

Explain each step in the G-protien mechanism

Answer 3

Question 4

Often times GCPR’s release/activate second messengers. What’s the three we need to know for this class? What do those messengers activate?

Answer 4

Not on slide but cAMP activates protien kinase A

Question 5

What is the scientific name for Insulin receptor?
What’s the broad mechanism?
What is Insulin?
What does binding activate inside the cell?

Answer 5

ALWAYS A DIMER

Question 6

Receptor Tyrosine Kinases have Kinase self-activation. What does this mean?

Answer 6

When insulin binds it changes the confirmation of the receptor to bring the two intracellular kinase domains close together.
These kinases phosphorylate tyrosines on each others chains. So it phosphorylates itself.

Question 7

Describe the insulin receptor mechanism specifically after kinase self-activation has happened.

Answer 7

After self-activation, IRS can bind then PI3 can bind (both phosphorylated) and PI3 makes PIP2->PIP3. Which can then recruit downstream proteins.

Question 8

After PIP3 is made, what is the downstream pathway we learned about? Explain the mechanism.

Answer 8

Question 9

Understand this slide