Serine Proteases Flashcards
1
Q
Define Proteases.
A
2
Q
What is the general peptide hydrolysis reaction?
A
3
Q
Define exopeptidase and endopeptidase.
A
4
Q
Define the structure of bovine trypsin, (a serine protease).
A
Pay attention to 2 things.
1. Proteins: Asp, Hst, Ser <- catalytic triad. Very important for function.
2. Specificity pocket: the thing that makes the protease unique.
5
Q
What are the three catalytic mechanisms of Serine Protease?
A
6
Q
What are some specific functions of Serine Protease you need to know? (5)
A
7
Q
Test: explain what’s going on at each step.
A
8
Q
What happens in going to happen to the oxyanion hole? Why is it there? What does it do?
A
9
Q
What differs chemotrypsin, trypsin, and elastase from each other?
A
Specificity pocket:
10
Q
Know this:
A
