Membrane Architecture II: Membrane Asymmetry and Integral Membrane Proteins Flashcards
Fill in blanks for pink!
(Purple is to test memorization of types lipids)
The is practically NO phosphatidylserine on outside of healthy cell.
Define what Flippase is. Why is it important?
They are lipid transporter proteins, that flip lipids from the outer to the inner membrane face.
These are important because you need to maintain the asymmetry of the membrane .
Require ATP! We don’t want equilibrium!
We know lateral diffusion across the cell membrane is fast. Why is transverse diffusion slow?
Because the hydrophilic head would have to go through all of the hydrophobic tails.
We’ve gone into flippase in detail, but there are two other enzymes that help keep the asymmetry of the membrane. What are they? What energy do they consume?
What are the two general classes of membrane proteins? Explain what defines each class.
Note: peripheral membranes only really react with the hydrophilic parts of the membrane or the integral proteins.
Explain why left to right it goes from less stable to more stable.
Describe what confirmation beta sheets need to make in order to be a transmembrane protein.
Define what Annular lipids are.
Lipids that preferentially block, bind, or stick to the surface of membrane proteins in biological cells.
