Principles Of Metabolism Flashcards
Define catabolism in relation to metabolism
Food broken down to release energy
Define anabolism in the context of metabolism
The molecules (broken down from food) are reassembled to build our own cells.
Principles of metabolism
For cellular respiration. What is the formula?
How much of the energy from that reaction is used to synthesize glucose?
How many ATP (about) are producing per molecule of glucose?
The other 45% is lost as heat!
Not all at once of course.
Explain how to determine oxidation state.
Test oxidation state: what is the oxidation for each carbon? Which molecule(s) have the most energy stored?
How would you define ATP as opposed to NADH?
What is the blue square showing? What about orange and purple? Extra: pink?
Pink is where the redox reaction happens.
What reaction is going on here? And the two molecules.
From top down: Reducing NAD+
How is ATP so energetically favorable to hydrolyze but doesn’t immediately break down?
Glucokinase is a great example of what coupled reactions look like. Explain how.
The AMP-PNP is just a stand in for ATP for visualization. In biology it’d be ATP. But the ATP next to the glucose is what you need to take away.
ATP is not the only metabolite with high phosphoryl transfer potential. How are these synthesized? And what are the used for?
What does Phosphocreatine do? How is it made?
PCr can be made because of how high the concentration of ATP is in the mitochondria, driving the reaction.
Notice: how even when ATP rapidly decreases the creatine phosphate stays a little longer, helping maintain energy to the muscles!
What is importante to notice in this enzyme?
Notice how this reaction can go in both directions.
What are these reaction pathways? (2), how can they go in exactly the opposite direction? What is the overall term called?
Term: metabolic flux
Going down: glycolysis
Going up: gluconeogenisis
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Summary slide:
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