Protein Domains and Protein Classification Flashcards
Define globular protein.
Compact globular structures.
Ex. Carboxypeptidase and Myoglobin
Define fibrous protein.
Form elongated fibrous proteins.
Ex. Keratin
Typically preform structural roles.
What is the pattern of amino acids in a coiled coil a-helix?
What is the pattern for the Collagen Triple Helix?
Test:
The a-helix is ____-handed.
The individual B-strand has a slight ______-handed twist.
In the B-sheet, the strands have a slight ______-handed twist when viewed IN the ________________________.
In a-keratin each individual a-helix is _______-handed. The ____ helices are twisted around each other in a ______-handed manner.
In collagen the ____ strands are twisted around each other in a ______-handed manner.
The a-helix is right-handed.
The individual B-strand has a slight right-handed twist.
In the B-sheet, the strands have a slight left-handed twist when viewed IN the plane of the sheet perpendicular to the strand.
In a-keratin each individual a-helix is right-handed. The two helices are twisted around each other in a left-handed manner.
In collagen the three strands are twisted around each other in a right-handed manner.
What are the 4 common super-secondary structures?
Define what a domain is.
Consists of a combination of secondary structural elements by turns and loops, that come together to form a compact folding unit.
** domains are compact folded nodules of a protein chain**
What are the three major types of domain classes?
What is the “TIM barrel” domain and what is a common protien with this folding?
Why are multi domain proteins common and good?
It brings multiple functionalities together in a single protein/a single polypeptide chain. Independent folding domains!
What do membrane proteins consist of and look like?
