Tramadol Flashcards
1
Q
what is tramadol
A
centrally-acting analgesic multi target analgesic
2
Q
how is tramadol thought to work?
A
- Binding of parent and M1 metabolite to μ-opioid receptors
- Weak inhibition of reuptake of norepinephrine and serotonin in the CNS
3
Q
what is Tramadol metabolized into?
A
O-desmethyl metabolite (M1)
4
Q
what are Tramadol and O-desmethyl metabolite both examples of
A
OP3-receptor agonists
