Cocaine

Question 1

What is Cocaine

Answer 1

A Noradrenaline reuptake inhibitor/sodium channel blocker and a is a local anaesthetic

Question 2

what is Cocaine used for

Answer 2

Cocaine is a local anaesthetic indicated for the introduction of local (topical) anaesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

Question 3

how does Cocaine produces anaesthesia

Answer 3

by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels, which are necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve

Question 4

what is special about Cocaine

Answer 4

is the only local anaesthetic with vasoconstrictive properties

Question 5

why does Cocaine have vasoconstrictive feature

Answer 5

This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system.

Question 6

What is responsible for the addictive property of cocaine

Answer 6

Its effect on dopamine levels

Question 7

What does cocaine bind differentially to

Answer 7

Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins

Question 8

what does Cocaine directly prevent the reuptake of

Answer 8

dopamine, serotonin, and norepinephrine into pre-synaptic neurons