Salbutamol

Question 1

what is salbutamol

Answer 1

beta2-adrenergic agonist

Question 2

what are the two isomers of salbutamol?

Answer 2

R and S isomer

Question 3

what is the R isomer levalbuterol responsible for ?

Answer 3

is responsible for bronchodilation

Question 4

what is the S-isomer responsible for?

Answer 4

increases bronchial reactivity

Question 5

what is the mechanism of action that for Salbutamol

Answer 5

mechanism of action is that it stimulates beta2-adrenergic receptors, leading to adenyl cyclase activation, increases in cAMP concentration, and therefore activation of cAMP-dependent protein kinase A.

Question 6

what is the role of the PKA?

Answer 6

PKA modulates myosin phosphorylation and lowers intracellular calcium concentrations causing smooth muscle relaxation and bronchodilation.

Question 7

as well as bronchodilation what does salbutamol do?

Answer 7

salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance