Calciferol Flashcards
how does Calciferol increase the serum Ca2+
1) Increasing GI absorption of phosphorus and Ca2+,
2) Increasing osteoclastic resorption, and
3) Increasing distal renal tubular reabsorption of Ca2+.
4) Promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, Ca2+ is absorbed through formation of a Ca2+-binding protein.
what is bioactive vitamin D
a steroid hormone
what is bioactive vitamin D for
regulating body levels of Ca2+ and phosphorus, and in mineralization of bone
what activates vita in D3
by 25-hydroxylation
what catalyses the activation of D3?
the 25-hydroxylase in the liver
what happens when The active form of vitamin D3 (calcitriol) binds to the vitamin D receptor
a complex if formed with another intracellular receptor, the retinoid-X receptor, that then function as transcription factors to generally activate gene expression.