Pralidoxime

Question 1

what is Pralidoxime

Answer 1

Cholinesterase reactivator

Question 2

what is Pralidoxime used as

Answer 2

is an antidote to organophosphate pesticides and chemicals

Question 3

what do organophosphates do?

Answer 3

bind to the esteratic site of acetylcholinesterase, resulting in its reversible inactivation

Question 4

what proceeds the inhibition of acetylcholinesterase?

Answer 4

acetylcholine accumulation in synapses, producing continuous stimulation of cholinergic fibers throughout the CNS.

Question 5

what happens if the Pralidome is given within 24hrs of Organophosphate exposure?

Answer 5

pralidoxime cleaves the phosphate-ester bond formed between the organophosphate and acetylcholinesterase, reactivating the acetylcholinesterase, allowing the breakdown of accumulated acetylcholine, and reestablishing the normal function of neuromuscular junctions

Question 6

Why would atropine also be given?

Answer 6

pralidoxime is less effective in relieving depression of the respiratory center, atropine is required concomitantly to block the effect of accumulated acetylcholine at this site.