Pethidine

Question 1

What is Pethidine

Answer 1

• Meperidine
• a synthetic opiate agonist
• kappa-opiate receptor agonist with

Question 2

What is Pethidine used for

Answer 2

• recommended for relief of moderate to severe acute pain

- local anesthetic effects

Question 3

Morphine vs Pethidine in terms of duration and onset of action

Answer 3

The onset of action is more rapid than morphine, but has a shorter duration of action.

Question 4

which one out of Morphine and Pethidine has a greater affinity for the kappa-receptor

Answer 4

Meperidine

Question 5

what are opiate receptors coupled with

Answer 5

G-protein receptors

Question 6

what do G-protein receptors activate

Answer 6

activate adenylate cyclase and the production of cAMP

Question 7

what do opioids do?

Answer 7

• Opioids decrease intracellular cAMP by inhibiting adenylate cyclase
• .the release of the nociceptive neurotransmitters substance P, GABA, dopamine, acetylcholine and noradrenaline and the hormones vasopressin, somatostatin, insulin and glucagon is inhibited

Question 8

what can receptors can opioids open and close? and what effects does this have

Answer 8

• opioids can close N-type voltage-operated calcium channels (OP2-receptor agonist)
• can open calcium-dependent
• inwardly rectifying potassium channels (OP3 and OP1 receptor agonist)
• resulting in reduced neuronal excitability.