Lidocaine

Question 1

what is Lidocaine

Answer 1

An anaesthetic agent (A sodium channel blocker). Also a class B drug

Question 2

what type of anesthetic is Lidocaine used for

Answer 2

local or regional anesthesia

Question 3

what does Lidocaine alter

Answer 3

-Signal conduction in neurons by blocking the signal propagation fast voltage-gated sodium channels in the neuronal cell membrane.

Question 4

what happens with sufficient blockage of the membrane of the postsynaptic neuron

Answer 4

• Because of this the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential.
• This creates the anaesthetic effect by both preventing the initiation of the pain signal, and the prevention of the propagation of that signal to the brain.

Question 5

describe Lidocaine as a class B drug

Answer 5

• Blocks voltage-sensitive sodium channels during phase 0 of the cardiac action potential,
• Thus slows and depresses impulse conduction.
• Lidocaine dissociates rapidly from the channel and almost completely between action potentials.

Question 6

what is Lidocaine used to treat

Answer 6

-Treat ventricular tachyarrhythmias associated with Myocardial infarction.

Question 7

how is Lidocaine used to ventricular tachyarrhythmias?

Answer 7

• Depresses Ventricular excitability

- increases the stimulation threshold of the ventricle during diastole

Question 8

how does Lidocaine affect the SAN?

Answer 8

Doesn’t, the SAN is unaffected

Question 9

how does Lidocaine affect tissues that are depolarised

Answer 9

• In tissue that is depolarised, or firing at a high frequency, dissociation between pulses is decreased
• This promotes channel blockade and depression of conduction.