Nicotine

Question 1

what is Nicotine

Answer 1

A Nicotinic acetylcholine agonist. a highly addictive stimulant drug

Question 2

how is Nicotine withdrawl syndrome treated?

Answer 2

Nicotine inhalers and patches are used to treat smoking withdrawl syndrome

Question 3

what is the mechanism of nictone action?

Answer 3

it is an agonist at nicotinic acetylcholine receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways, opening the channel and allowing conductance of sodium, calcium, and potassium. This leads to depolarization, activates voltage-gated calcium channels and the release of dopamine into the synapse.

Question 4

what is responsible for the euphoric and addictive properties of nicotine

Answer 4

Dopamine binding to its receptors

Question 5

what happens to nicotine at the Adrenal medulla

Answer 5

Nicotine binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla.

This binding opens the ion channel allowing influx of sodium, causing depolarization, activation of the voltage-gated calcium channels, triggering epinephrine release from intracellular vesicles into the bloodstream, causing vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar