Raloxifene

Question 1

what is Raloxifene

Answer 1

A Selective estrogen receptor modulator

Question 2

what does Raloxifene do

Answer 2

, produces estrogen-like effects on bone and lipid metabolism, while antagonizing the effects of estrogen on breast and uterine tissue

Question 3

what does Ralixofene do in the bone?

Answer 3

binds to the estrogen receptors, resulting in reduced bone resorption and increased bone mineral density in postmenopausal women, slowing the rate of bone loss

Question 4

how does Raloxifene slow the rate of bone loss

Answer 4

via activation of transforming growth factor-β3, which is a bone matrix protein with antiosteoclastic properties. In addition Raloxifene can inhibit the proliferation of preosteoclastic cells

Question 5

what else does Raloxifene inhibit?

Answer 5

can inhibit the proliferation of preosteoclastic cells

Question 6

what else does Raloxifene antagonise?

Answer 6

the effects of estrogen on mammary and uterine tissue

Question 7

what does Raloxifene d in mammary and uterine tissue

Answer 7

Raloxifene prevents the transcriptional activation of genes containing the estrogen response element

Question 8

descibe the two possibilities by which Raloxifene prevents the transcriptional activation of genes containing the estrogen response

Answer 8

• Raloxifene’s tissue-specific estrogen agonist or antagonist activity is dependent on the structural differences between the raloxifene-estrogen receptor complex and the estrogen-estrogen receptor complex.
• The presence of at least 2 estrogen receptors (ERα, ERβ) may determine the tissue specificity of Raloxifene.