Dexamphetamine Flashcards

1
Q

what is Dexamphetamine

A

Noradrenaline releaser

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2
Q

what are amphetamines

A

agents with CNS stimulant activity

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3
Q

what are the peripheral actions of the amphetamines?

A

Peripheral actions include elevations of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action

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4
Q

The mechanism of action of Dexamphetamine is unknown, However what is the possible mechanisms of Dexamphetamine

A

1) Stimulation of the release of norepinephrine from central adrenergic receptors.
2) At higher dosages, it causes dopamine release from the mesocorticolimbic system and the nigrostriatal systems by reversal of the monoamine transporters.
3) Act as a direct agonist on central 5-HT receptors
4) Inhibit monoamine oxidase (MAO).
5) In the periphery cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors.

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