Calcitonin/Salcatonin Flashcards
what makes Calcitonin
produced by the thyroid gland
what is Calcitonin/Salcatonin
: A Hormone produced by the Thyroid gland
what is Calcitonin/Salcatonin used for
important in the control of the calcium concentration within the blood
how does Calcitonin/Salcatonin work
It antagonises the action of parathyroid hormone
what needs to happen for Calcitonin/Salcatonin to work
calcitonin acts as an agonist and binds to the calcitonin receptor
what is the calcitonin receptor is an example of
a GPCR
what is the effect of calcitonin binding to the calcitonin receptor
This activates the cAMP and calcium signalling pathways, leading to the enhance production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), greater calcium retention and enhanced bone density. This leads to a net increase in bone mass and a reduction in plasma calcium levels
In addition to affecting osteoclasts what else does Calcitonin do?
, in also stimulates bone building by osteoblasts.
where is the calcitonin receptor mostly found in
found primarily in osteoclasts
what does calcitonin also promote and how
promotes the renal excretion of calcium, phosphate, sodium, magnesium, and potassium ions by decreasing tubular reabsorption, and so increases jejunal secretion of water, sodium, potassium, and chloride ions.
